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Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma

Olmutinib (OTB, Olita™) is an orally available third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI). It was developed by Boehringer Ingelheim and Hanmi Pharmaceutical Co. Ltd for the cure of non-small cell lung cancer (NSCLC). In May 2016, OTB was approved in South...

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Detalles Bibliográficos
Autores principales:	Attwa, Mohamed W., Kadi, Adnan A., Darwish, Hany W., Abdelhameed, Ali S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091481/ https://www.ncbi.nlm.nih.gov/pubmed/35558213 http://dx.doi.org/10.1039/c8ra08161a

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