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Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report

Primary giant cell tumors of soft tissues (GCT-STs) are extremely rare soft tissue tumors located both in superficial and in deep soft tissues. Clinically, GCT-ST manifests as a slow-growing, well-defined, painless mass. We report a case of an 88-year-old female patient with upper abdominal distensi...

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Autores principales: Chen, Piaopiao, Hu, Qiang, Wu, Jinfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091500/
https://www.ncbi.nlm.nih.gov/pubmed/35574549
http://dx.doi.org/10.3389/fsurg.2022.830852
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author Chen, Piaopiao
Hu, Qiang
Wu, Jinfeng
author_facet Chen, Piaopiao
Hu, Qiang
Wu, Jinfeng
author_sort Chen, Piaopiao
collection PubMed
description Primary giant cell tumors of soft tissues (GCT-STs) are extremely rare soft tissue tumors located both in superficial and in deep soft tissues. Clinically, GCT-ST manifests as a slow-growing, well-defined, painless mass. We report a case of an 88-year-old female patient with upper abdominal distension, fever, and anemia. Laparoscopic exploration revealed a tumor located in the left lobe of the liver with localized rupture and hemorrhage. Postoperative pathology revealed that the tumor was composed of monocytes and osteoclast-like multinucleated giant cells, accompanied by extensive hemorrhage, necrosis, and cytologic atypia. Because mitotic cells are difficult to be detected in pathological diagnosis, combined with immunohistochemistry, the tumor was diagnosed as a giant cell tumor of soft tissue. This case report highlights the primary choice of histology and immunohistochemistry for the correct diagnosis of GCT-ST because preoperative radiological diagnosis is nonspecific and prone to mistakes.
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spelling pubmed-90915002022-05-12 Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report Chen, Piaopiao Hu, Qiang Wu, Jinfeng Front Surg Surgery Primary giant cell tumors of soft tissues (GCT-STs) are extremely rare soft tissue tumors located both in superficial and in deep soft tissues. Clinically, GCT-ST manifests as a slow-growing, well-defined, painless mass. We report a case of an 88-year-old female patient with upper abdominal distension, fever, and anemia. Laparoscopic exploration revealed a tumor located in the left lobe of the liver with localized rupture and hemorrhage. Postoperative pathology revealed that the tumor was composed of monocytes and osteoclast-like multinucleated giant cells, accompanied by extensive hemorrhage, necrosis, and cytologic atypia. Because mitotic cells are difficult to be detected in pathological diagnosis, combined with immunohistochemistry, the tumor was diagnosed as a giant cell tumor of soft tissue. This case report highlights the primary choice of histology and immunohistochemistry for the correct diagnosis of GCT-ST because preoperative radiological diagnosis is nonspecific and prone to mistakes. Frontiers Media S.A. 2022-04-27 /pmc/articles/PMC9091500/ /pubmed/35574549 http://dx.doi.org/10.3389/fsurg.2022.830852 Text en Copyright © 2022 Chen, Hu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Chen, Piaopiao
Hu, Qiang
Wu, Jinfeng
Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title_full Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title_fullStr Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title_full_unstemmed Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title_short Giant Cell Tumor of Soft Tissue—A Rare Cause of Mass in the Liver: A Case Report
title_sort giant cell tumor of soft tissue—a rare cause of mass in the liver: a case report
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091500/
https://www.ncbi.nlm.nih.gov/pubmed/35574549
http://dx.doi.org/10.3389/fsurg.2022.830852
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