Cargando…
Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery
BACKGROUND: Previous studies have reported that children who were admitted to the ICU experienced a significant decrease in sleep quality compared to home. We investigated the effects of dexmedetomidine as an adjunct to sufentanil on the sleep in children admitted to the ICU on the first night after...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091560/ https://www.ncbi.nlm.nih.gov/pubmed/35573948 http://dx.doi.org/10.3389/fped.2022.871809 |
_version_ | 1784704949556346880 |
---|---|
author | Zhang, Xian Chang, Li Pan, Shou-Dong Yan, Fu-Xia |
author_facet | Zhang, Xian Chang, Li Pan, Shou-Dong Yan, Fu-Xia |
author_sort | Zhang, Xian |
collection | PubMed |
description | BACKGROUND: Previous studies have reported that children who were admitted to the ICU experienced a significant decrease in sleep quality compared to home. We investigated the effects of dexmedetomidine as an adjunct to sufentanil on the sleep in children admitted to the ICU on the first night after major surgery. METHODS: This is a prospective study From January to February 2022. Clinical trial number: ChiCTR2200055768, http://www.chictr.org.cn. Fifty-four children aged 1–10 years old children undergoing major laparoscopic surgery were recruited and randomly assigned to either the DEX group, in which intravenous dexmedetomidine (0.3 ug/kg/h) and sufentanil (0.04 ug/kg/h) were continuously infused intravenously for post-operative analgesia; or the SUF group, in which only sufentanil (0.04 ug/kg/h) was continuously infused. Patients were monitored with polysomnography (PSG) on the first night after surgery for 12 h. PSG, sleep architecture, physiologic variables and any types of side effects related to anesthesia and analgesia were recorded. The differences between the two groups were assessed using the chi-square and Wilcoxon rank-sum tests. RESULTS: Fifty-four children completed data collection, of which thirty-four were 1–6 years old and twenty were aged >6 years. Compared to the SUF group, subjects in the DEX group aged 1–6 years displayed increased stage 2 sleep duration (P = 0.02) and light sleep duration (P = 0.02). Subjects aged >6 years in the DEX group also displayed increased stage 2 sleep duration (P = 0.035) and light sleep duration (P = 0.018), but decreased REM sleep percentage (P = 0). Additionally, the heart rate and blood pressure results differed between age groups, with the heart rates of subjects aged >6 years in DEX group decreasing at most time points compared to SUF group (P < 0.05). CONCLUSION: Dexmedetomidine prolonged N2 sleep and light sleep duration in the pediatric ICU after surgery but had different effects on the heart rate and blood pressure of subjects in different age groups. |
format | Online Article Text |
id | pubmed-9091560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90915602022-05-12 Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery Zhang, Xian Chang, Li Pan, Shou-Dong Yan, Fu-Xia Front Pediatr Pediatrics BACKGROUND: Previous studies have reported that children who were admitted to the ICU experienced a significant decrease in sleep quality compared to home. We investigated the effects of dexmedetomidine as an adjunct to sufentanil on the sleep in children admitted to the ICU on the first night after major surgery. METHODS: This is a prospective study From January to February 2022. Clinical trial number: ChiCTR2200055768, http://www.chictr.org.cn. Fifty-four children aged 1–10 years old children undergoing major laparoscopic surgery were recruited and randomly assigned to either the DEX group, in which intravenous dexmedetomidine (0.3 ug/kg/h) and sufentanil (0.04 ug/kg/h) were continuously infused intravenously for post-operative analgesia; or the SUF group, in which only sufentanil (0.04 ug/kg/h) was continuously infused. Patients were monitored with polysomnography (PSG) on the first night after surgery for 12 h. PSG, sleep architecture, physiologic variables and any types of side effects related to anesthesia and analgesia were recorded. The differences between the two groups were assessed using the chi-square and Wilcoxon rank-sum tests. RESULTS: Fifty-four children completed data collection, of which thirty-four were 1–6 years old and twenty were aged >6 years. Compared to the SUF group, subjects in the DEX group aged 1–6 years displayed increased stage 2 sleep duration (P = 0.02) and light sleep duration (P = 0.02). Subjects aged >6 years in the DEX group also displayed increased stage 2 sleep duration (P = 0.035) and light sleep duration (P = 0.018), but decreased REM sleep percentage (P = 0). Additionally, the heart rate and blood pressure results differed between age groups, with the heart rates of subjects aged >6 years in DEX group decreasing at most time points compared to SUF group (P < 0.05). CONCLUSION: Dexmedetomidine prolonged N2 sleep and light sleep duration in the pediatric ICU after surgery but had different effects on the heart rate and blood pressure of subjects in different age groups. Frontiers Media S.A. 2022-04-27 /pmc/articles/PMC9091560/ /pubmed/35573948 http://dx.doi.org/10.3389/fped.2022.871809 Text en Copyright © 2022 Zhang, Chang, Pan and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Zhang, Xian Chang, Li Pan, Shou-Dong Yan, Fu-Xia Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title_full | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title_fullStr | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title_full_unstemmed | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title_short | Dexmedetomidine Improves Non-rapid Eye Movement Stage 2 Sleep in Children in the Intensive Care Unit on the First Night After Laparoscopic Surgery |
title_sort | dexmedetomidine improves non-rapid eye movement stage 2 sleep in children in the intensive care unit on the first night after laparoscopic surgery |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091560/ https://www.ncbi.nlm.nih.gov/pubmed/35573948 http://dx.doi.org/10.3389/fped.2022.871809 |
work_keys_str_mv | AT zhangxian dexmedetomidineimprovesnonrapideyemovementstage2sleepinchildrenintheintensivecareunitonthefirstnightafterlaparoscopicsurgery AT changli dexmedetomidineimprovesnonrapideyemovementstage2sleepinchildrenintheintensivecareunitonthefirstnightafterlaparoscopicsurgery AT panshoudong dexmedetomidineimprovesnonrapideyemovementstage2sleepinchildrenintheintensivecareunitonthefirstnightafterlaparoscopicsurgery AT yanfuxia dexmedetomidineimprovesnonrapideyemovementstage2sleepinchildrenintheintensivecareunitonthefirstnightafterlaparoscopicsurgery |