Design and characterization of chionodracine-derived antimicrobial peptides with enhanced activity against drug-resistant human pathogens

Starting from the sequence of the amphipathic α-helix of chionodracine (Cnd, 22 amino acids), we designed a series of mutants to increase Cnd's antimicrobial activity and selectivity toward prokaryotic cells and drug-resistant bacterial pathogens. We characterized these new Cnd-derived peptides...

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Detalles Bibliográficos
Autores principales: Olivieri, Cristina, Bugli, Francesca, Menchinelli, Giulia, Veglia, Gianluigi, Buonocore, Francesco, Scapigliati, Giuseppe, Stocchi, Valentina, Ceccacci, Francesca, Papi, Massimiliano, Sanguinetti, Maurizio, Porcelli, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091591/
https://www.ncbi.nlm.nih.gov/pubmed/35559296
http://dx.doi.org/10.1039/c8ra08065h

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