Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides

We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki–Hiyama–Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This ap...

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Autores principales: Kumbhar, Sharad V., Chen, Chinpiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091628/
https://www.ncbi.nlm.nih.gov/pubmed/35559290
http://dx.doi.org/10.1039/c8ra09575b
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author Kumbhar, Sharad V.
Chen, Chinpiao
author_facet Kumbhar, Sharad V.
Chen, Chinpiao
author_sort Kumbhar, Sharad V.
collection PubMed
description We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki–Hiyama–Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This approach was applied to synthesize (S)-cytosporone E at a 71% yield in three steps.
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spelling pubmed-90916282022-05-11 Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides Kumbhar, Sharad V. Chen, Chinpiao RSC Adv Chemistry We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki–Hiyama–Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This approach was applied to synthesize (S)-cytosporone E at a 71% yield in three steps. The Royal Society of Chemistry 2018-12-12 /pmc/articles/PMC9091628/ /pubmed/35559290 http://dx.doi.org/10.1039/c8ra09575b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kumbhar, Sharad V.
Chen, Chinpiao
Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title_full Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title_fullStr Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title_full_unstemmed Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title_short Enantioselective Nozaki–Hiyama–Kishi allylation-lactonization for the syntheses of 3-substituted phthalides
title_sort enantioselective nozaki–hiyama–kishi allylation-lactonization for the syntheses of 3-substituted phthalides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091628/
https://www.ncbi.nlm.nih.gov/pubmed/35559290
http://dx.doi.org/10.1039/c8ra09575b
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AT chenchinpiao enantioselectivenozakihiyamakishiallylationlactonizationforthesynthesesof3substitutedphthalides

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