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Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method

Rotundic acid (RA), an ursane-type pentacyclic triterpene acid isolated from the dried barks of Ilex rotunda Thunb. (Aquifoliaceae), possesses diverse bioactivities. To further study its pharmacokinetics, a simple and sensitive liquid chromatography with triple quadrupole mass spectrometry (LC-QqQ-M...

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Detalles Bibliográficos
Autores principales:	Shang, Haihua, Dai, Xiaohan, Li, Mi, Kai, Yueyi, Liu, Zerong, Wang, Min, Li, Quansheng, Gu, Yuan, Liu, Changxiao, Si, Duanyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091740/ https://www.ncbi.nlm.nih.gov/pubmed/35582394 http://dx.doi.org/10.1016/j.jpha.2021.03.008

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