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Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy
Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(II)/Fe(III) are used to induce the formation of indocyanine green (ICG) J-aggregates. Further, the sheet-like J-a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091788/ https://www.ncbi.nlm.nih.gov/pubmed/35582644 http://dx.doi.org/10.1016/j.ajps.2022.01.003 |
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author | Chen, Chen Yang, Shan Liu, Yufei Qiu, Yue Yao, Jing |
author_facet | Chen, Chen Yang, Shan Liu, Yufei Qiu, Yue Yao, Jing |
author_sort | Chen, Chen |
collection | PubMed |
description | Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(II)/Fe(III) are used to induce the formation of indocyanine green (ICG) J-aggregates. Further, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid (GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. The as-designed nanoassembly is formed spontaneously in aqueous environment via π-π stacking, electrostatic interaction, and hydrophobic force, exhibiting enhanced photostability of ICG and outstanding reactive oxygen species (ROS) generation ability. Moreover, significant inhibition of tumor growth by the synergetic effect of phototherapy and chemotherapy is verified in a subcutaneous 4T1 tumors model. In conclusion, this work not only presents a facile and green approach to manufacture carrier-free nanodrugs, but also establishes a universal platform that has potential application in the co-delivery of near-infrared dye and hydrophobic molecules. |
format | Online Article Text |
id | pubmed-9091788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-90917882022-05-16 Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy Chen, Chen Yang, Shan Liu, Yufei Qiu, Yue Yao, Jing Asian J Pharm Sci Original Research Paper Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(II)/Fe(III) are used to induce the formation of indocyanine green (ICG) J-aggregates. Further, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid (GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. The as-designed nanoassembly is formed spontaneously in aqueous environment via π-π stacking, electrostatic interaction, and hydrophobic force, exhibiting enhanced photostability of ICG and outstanding reactive oxygen species (ROS) generation ability. Moreover, significant inhibition of tumor growth by the synergetic effect of phototherapy and chemotherapy is verified in a subcutaneous 4T1 tumors model. In conclusion, this work not only presents a facile and green approach to manufacture carrier-free nanodrugs, but also establishes a universal platform that has potential application in the co-delivery of near-infrared dye and hydrophobic molecules. Shenyang Pharmaceutical University 2022-03 2022-02-25 /pmc/articles/PMC9091788/ /pubmed/35582644 http://dx.doi.org/10.1016/j.ajps.2022.01.003 Text en © 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Paper Chen, Chen Yang, Shan Liu, Yufei Qiu, Yue Yao, Jing Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title | Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title_full | Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title_fullStr | Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title_full_unstemmed | Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title_short | Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy |
title_sort | metal ions-bridged j-aggregation mediated nanoassembly composition for breast cancer phototherapy |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091788/ https://www.ncbi.nlm.nih.gov/pubmed/35582644 http://dx.doi.org/10.1016/j.ajps.2022.01.003 |
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