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Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth

In fossil tetrapods, limb bone histology is considered the most reliable tool not only for inferring skeletal maturity—a crucial assessment in palaeobiological and evolutionary studies—but also for evaluating the growth dynamics within the ontogenetic window represented by the primary bone cortex. D...

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Autores principales: Prondvai, Edina, Kocsis, Adam T., Abourachid, Anick, Adriaens, Dominique, Godefroit, Pascal, Hu, Dong-Yu, Butler, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091851/
https://www.ncbi.nlm.nih.gov/pubmed/35582660
http://dx.doi.org/10.1098/rsos.211893
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author Prondvai, Edina
Kocsis, Adam T.
Abourachid, Anick
Adriaens, Dominique
Godefroit, Pascal
Hu, Dong-Yu
Butler, Richard J.
author_facet Prondvai, Edina
Kocsis, Adam T.
Abourachid, Anick
Adriaens, Dominique
Godefroit, Pascal
Hu, Dong-Yu
Butler, Richard J.
author_sort Prondvai, Edina
collection PubMed
description In fossil tetrapods, limb bone histology is considered the most reliable tool not only for inferring skeletal maturity—a crucial assessment in palaeobiological and evolutionary studies—but also for evaluating the growth dynamics within the ontogenetic window represented by the primary bone cortex. Due to its complex relationship with bone growth and functional maturation, primary cortical vascularity is an indispensable osteohistological character for reconstructing growth dynamics, especially in the context of various developmental strategies along the precocial–altricial spectrum. Using this concept as our working hypothesis, we developed a new quantitative osteohistological parameter, radial porosity profile (RPP), that captures relative cortical porosity changes in limb bones as trajectories. We built a proof-of-concept RPP dataset on extant birds, then added fossil paravian dinosaurs and performed a set of trajectory-grouping analyses to identify potential RPP categories and evaluate them in the context of our ontogeny—developmental strategy working hypothesis. We found that RPPs, indeed, reflect important developmental features within and across elements, specimens and taxa, supporting their analytical power. Our RPPs also revealed unexpected potential osteohistological correlates of growth and functional development of limb bones. The diverse potential applications of RPPs open up new research directions in the evolution of locomotor ontogeny.
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spelling pubmed-90918512022-05-16 Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth Prondvai, Edina Kocsis, Adam T. Abourachid, Anick Adriaens, Dominique Godefroit, Pascal Hu, Dong-Yu Butler, Richard J. R Soc Open Sci Organismal and Evolutionary Biology In fossil tetrapods, limb bone histology is considered the most reliable tool not only for inferring skeletal maturity—a crucial assessment in palaeobiological and evolutionary studies—but also for evaluating the growth dynamics within the ontogenetic window represented by the primary bone cortex. Due to its complex relationship with bone growth and functional maturation, primary cortical vascularity is an indispensable osteohistological character for reconstructing growth dynamics, especially in the context of various developmental strategies along the precocial–altricial spectrum. Using this concept as our working hypothesis, we developed a new quantitative osteohistological parameter, radial porosity profile (RPP), that captures relative cortical porosity changes in limb bones as trajectories. We built a proof-of-concept RPP dataset on extant birds, then added fossil paravian dinosaurs and performed a set of trajectory-grouping analyses to identify potential RPP categories and evaluate them in the context of our ontogeny—developmental strategy working hypothesis. We found that RPPs, indeed, reflect important developmental features within and across elements, specimens and taxa, supporting their analytical power. Our RPPs also revealed unexpected potential osteohistological correlates of growth and functional development of limb bones. The diverse potential applications of RPPs open up new research directions in the evolution of locomotor ontogeny. The Royal Society 2022-05-11 /pmc/articles/PMC9091851/ /pubmed/35582660 http://dx.doi.org/10.1098/rsos.211893 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Organismal and Evolutionary Biology
Prondvai, Edina
Kocsis, Adam T.
Abourachid, Anick
Adriaens, Dominique
Godefroit, Pascal
Hu, Dong-Yu
Butler, Richard J.
Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title_full Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title_fullStr Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title_full_unstemmed Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title_short Radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
title_sort radial porosity profiles: a new bone histological method for comparative developmental analysis of diametric limb bone growth
topic Organismal and Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091851/
https://www.ncbi.nlm.nih.gov/pubmed/35582660
http://dx.doi.org/10.1098/rsos.211893
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