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Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids
A library of 4H-chromene derivatives with heterocyclic substituent's at the 3 and 4-positions was synthesized in a convenient DBU catalysed three component synthesis between salicylaldehyde, acetonitrile derivatives and thiazolidinedione to afford 2-amino-3-benzothiazole-4-heterocycle-4H-chrome...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091940/ https://www.ncbi.nlm.nih.gov/pubmed/35558789 http://dx.doi.org/10.1039/c8ra08262f |
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author | Pazhanivel, Lakshmanan Gnanasambandam, Vasuki |
author_facet | Pazhanivel, Lakshmanan Gnanasambandam, Vasuki |
author_sort | Pazhanivel, Lakshmanan |
collection | PubMed |
description | A library of 4H-chromene derivatives with heterocyclic substituent's at the 3 and 4-positions was synthesized in a convenient DBU catalysed three component synthesis between salicylaldehyde, acetonitrile derivatives and thiazolidinedione to afford 2-amino-3-benzothiazole-4-heterocycle-4H-chromenes and 2-amino-3-thiophenoyl-4-heterocycle-4H-chromenes derivatives in ethanol and a mixture of ethanol and water (1 : 1) at room temperature. The significance of this protocol is the feasibility of incorporating substituents simultaneously at the 3 and 4 positions of 4H-chromenes in an efficient three component reaction. |
format | Online Article Text |
id | pubmed-9091940 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90919402022-05-11 Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids Pazhanivel, Lakshmanan Gnanasambandam, Vasuki RSC Adv Chemistry A library of 4H-chromene derivatives with heterocyclic substituent's at the 3 and 4-positions was synthesized in a convenient DBU catalysed three component synthesis between salicylaldehyde, acetonitrile derivatives and thiazolidinedione to afford 2-amino-3-benzothiazole-4-heterocycle-4H-chromenes and 2-amino-3-thiophenoyl-4-heterocycle-4H-chromenes derivatives in ethanol and a mixture of ethanol and water (1 : 1) at room temperature. The significance of this protocol is the feasibility of incorporating substituents simultaneously at the 3 and 4 positions of 4H-chromenes in an efficient three component reaction. The Royal Society of Chemistry 2018-12-13 /pmc/articles/PMC9091940/ /pubmed/35558789 http://dx.doi.org/10.1039/c8ra08262f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Pazhanivel, Lakshmanan Gnanasambandam, Vasuki Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title | Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title_full | Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title_fullStr | Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title_full_unstemmed | Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title_short | Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids |
title_sort | design and synthesis of benzothiazole/thiophene-4h-chromene hybrids |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091940/ https://www.ncbi.nlm.nih.gov/pubmed/35558789 http://dx.doi.org/10.1039/c8ra08262f |
work_keys_str_mv | AT pazhanivellakshmanan designandsynthesisofbenzothiazolethiophene4hchromenehybrids AT gnanasambandamvasuki designandsynthesisofbenzothiazolethiophene4hchromenehybrids |