Cargando…

Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study

INTRODUCTION: Septic shock, largely caused by intestinal perforation, is the most common critical illness in intensive care unit (ICU). As an important quality control strategy in ICU, deep vein thrombosis (DVT) prevention is routinely used in the treatment of septic shock. Nevertheless, the effects...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lu, Ma, Xudong, He, Huaiwu, Su, Longxiang, Guo, Yanhong, Shan, Guangliang, Wang, Ye, Zhou, Xiang, Liu, Dawei, Long, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092133/
https://www.ncbi.nlm.nih.gov/pubmed/35572994
http://dx.doi.org/10.3389/fmed.2022.878075
_version_ 1784705078414802944
author Wang, Lu
Ma, Xudong
He, Huaiwu
Su, Longxiang
Guo, Yanhong
Shan, Guangliang
Wang, Ye
Zhou, Xiang
Liu, Dawei
Long, Yun
author_facet Wang, Lu
Ma, Xudong
He, Huaiwu
Su, Longxiang
Guo, Yanhong
Shan, Guangliang
Wang, Ye
Zhou, Xiang
Liu, Dawei
Long, Yun
author_sort Wang, Lu
collection PubMed
description INTRODUCTION: Septic shock, largely caused by intestinal perforation, is the most common critical illness in intensive care unit (ICU). As an important quality control strategy in ICU, deep vein thrombosis (DVT) prevention is routinely used in the treatment of septic shock. Nevertheless, the effects of DVT prevention on septic shock are not fully revealed. This study was thus designed to investigate the effects of DVT prevention on septic shock caused by intestinal perforation in China. METHODS: A total of 463 hospitals were enrolled in a survey, led by the China National Critical Care Quality Control Center (China NCCQC) from January 1, 2018 to December 31, 2018. The association between DVT prevention, including pharmacological prophylaxis and mechanical prophylaxis, and outcomes, such as prognosis, complications, hospital stays, and hospitalization costs, was determined in the present study. MAIN RESULTS: Notably, the increased rates of DVT prevention were not associated with the onset of complications in patients with septic shock caused by intestinal perforation (p > 0.05). In addition, even though increased DVT prevention did not affect hospital stays, it significantly decreased the discharge rates without doctor's order in patients with septic shock caused by intestinal perforation (p < 0.05). Nevertheless, it should be noted that the rates of pharmacological prophylaxis but not mechanical prophylaxis were significantly associated with the costs of septic shock caused by intestinal perforation (p < 0.05). Although increased total rates of DVT prevention and the rates of mechanical prophylaxis did not reduce the mortality in patients with septic shock caused by intestinal perforation, the higher frequent intervention using pharmacological prophylaxis indicated the lower mortality of these patients (p < 0.05). CONCLUSIONS: DVT prevention by any means is a safe therapeutic strategy for treating septic shock caused by intestinal perforation, and pharmacological prophylaxis reduced the mortality of patients with septic shock caused by intestinal perforation.
format Online
Article
Text
id pubmed-9092133
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90921332022-05-12 Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study Wang, Lu Ma, Xudong He, Huaiwu Su, Longxiang Guo, Yanhong Shan, Guangliang Wang, Ye Zhou, Xiang Liu, Dawei Long, Yun Front Med (Lausanne) Medicine INTRODUCTION: Septic shock, largely caused by intestinal perforation, is the most common critical illness in intensive care unit (ICU). As an important quality control strategy in ICU, deep vein thrombosis (DVT) prevention is routinely used in the treatment of septic shock. Nevertheless, the effects of DVT prevention on septic shock are not fully revealed. This study was thus designed to investigate the effects of DVT prevention on septic shock caused by intestinal perforation in China. METHODS: A total of 463 hospitals were enrolled in a survey, led by the China National Critical Care Quality Control Center (China NCCQC) from January 1, 2018 to December 31, 2018. The association between DVT prevention, including pharmacological prophylaxis and mechanical prophylaxis, and outcomes, such as prognosis, complications, hospital stays, and hospitalization costs, was determined in the present study. MAIN RESULTS: Notably, the increased rates of DVT prevention were not associated with the onset of complications in patients with septic shock caused by intestinal perforation (p > 0.05). In addition, even though increased DVT prevention did not affect hospital stays, it significantly decreased the discharge rates without doctor's order in patients with septic shock caused by intestinal perforation (p < 0.05). Nevertheless, it should be noted that the rates of pharmacological prophylaxis but not mechanical prophylaxis were significantly associated with the costs of septic shock caused by intestinal perforation (p < 0.05). Although increased total rates of DVT prevention and the rates of mechanical prophylaxis did not reduce the mortality in patients with septic shock caused by intestinal perforation, the higher frequent intervention using pharmacological prophylaxis indicated the lower mortality of these patients (p < 0.05). CONCLUSIONS: DVT prevention by any means is a safe therapeutic strategy for treating septic shock caused by intestinal perforation, and pharmacological prophylaxis reduced the mortality of patients with septic shock caused by intestinal perforation. Frontiers Media S.A. 2022-04-27 /pmc/articles/PMC9092133/ /pubmed/35572994 http://dx.doi.org/10.3389/fmed.2022.878075 Text en Copyright © 2022 Wang, Ma, He, Su, Guo, Shan, Wang, Zhou, Liu and Long. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wang, Lu
Ma, Xudong
He, Huaiwu
Su, Longxiang
Guo, Yanhong
Shan, Guangliang
Wang, Ye
Zhou, Xiang
Liu, Dawei
Long, Yun
Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title_full Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title_fullStr Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title_full_unstemmed Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title_short Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study
title_sort association between different dvt prevention methods and outcomes of septic shock caused by intestinal perforation in china: a cross-sectional study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092133/
https://www.ncbi.nlm.nih.gov/pubmed/35572994
http://dx.doi.org/10.3389/fmed.2022.878075
work_keys_str_mv AT wanglu associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT maxudong associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT hehuaiwu associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT sulongxiang associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT guoyanhong associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT shanguangliang associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT wangye associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT zhouxiang associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT liudawei associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy
AT longyun associationbetweendifferentdvtpreventionmethodsandoutcomesofsepticshockcausedbyintestinalperforationinchinaacrosssectionalstudy