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Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment

Multisystem inflammatory syndrome in adults (MIS-A) has been reported as a rare but severe consequence of COVID-19 infection. Adult patients were more likely to present with hypotension and cardiac illness when compared with multisystem inflammatory syndrome in children. Although the exact prevalenc...

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Autores principales: Rojnukoolwanich, Thitirat, Kuagoolwongse, Chankanok, Vibhagool, Asda, Pongpirul, Krit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092143/
https://www.ncbi.nlm.nih.gov/pubmed/35537767
http://dx.doi.org/10.1136/bcr-2021-248520
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author Rojnukoolwanich, Thitirat
Kuagoolwongse, Chankanok
Vibhagool, Asda
Pongpirul, Krit
author_facet Rojnukoolwanich, Thitirat
Kuagoolwongse, Chankanok
Vibhagool, Asda
Pongpirul, Krit
author_sort Rojnukoolwanich, Thitirat
collection PubMed
description Multisystem inflammatory syndrome in adults (MIS-A) has been reported as a rare but severe consequence of COVID-19 infection. Adult patients were more likely to present with hypotension and cardiac illness when compared with multisystem inflammatory syndrome in children. Although the exact prevalence of MIS-A is unknown, more cases have been observed in men and younger adults. The pathophysiology of MIS-A is also unclear, but is thought to be caused by a delayed, dysregulated immune response. Given no established guideline for treatment of MIS-A, treatment has been based on case reports. We present a case of MIS-A in a woman in her 60s who had severe hypotension, progressive dyspnoea, massive pleural effusion, hypoxaemia, thyroiditis and multiple organ failure, which dramatically improved after treatment with corticosteroid and interleukin 6 inhibitor.
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spelling pubmed-90921432022-05-27 Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment Rojnukoolwanich, Thitirat Kuagoolwongse, Chankanok Vibhagool, Asda Pongpirul, Krit BMJ Case Rep Case Reports: Unusual presentation of more common disease/injury Multisystem inflammatory syndrome in adults (MIS-A) has been reported as a rare but severe consequence of COVID-19 infection. Adult patients were more likely to present with hypotension and cardiac illness when compared with multisystem inflammatory syndrome in children. Although the exact prevalence of MIS-A is unknown, more cases have been observed in men and younger adults. The pathophysiology of MIS-A is also unclear, but is thought to be caused by a delayed, dysregulated immune response. Given no established guideline for treatment of MIS-A, treatment has been based on case reports. We present a case of MIS-A in a woman in her 60s who had severe hypotension, progressive dyspnoea, massive pleural effusion, hypoxaemia, thyroiditis and multiple organ failure, which dramatically improved after treatment with corticosteroid and interleukin 6 inhibitor. BMJ Publishing Group 2022-05-10 /pmc/articles/PMC9092143/ /pubmed/35537767 http://dx.doi.org/10.1136/bcr-2021-248520 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Unusual presentation of more common disease/injury
Rojnukoolwanich, Thitirat
Kuagoolwongse, Chankanok
Vibhagool, Asda
Pongpirul, Krit
Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title_full Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title_fullStr Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title_full_unstemmed Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title_short Multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
title_sort multisystem inflammatory syndrome in an adult with severe hypoxaemia and thyroiditis responsive to corticosteroid and interleukin 6 inhibitor treatment
topic Case Reports: Unusual presentation of more common disease/injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092143/
https://www.ncbi.nlm.nih.gov/pubmed/35537767
http://dx.doi.org/10.1136/bcr-2021-248520
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