Electrochemiluminescence of gold nanoparticles and gold nanoparticle-labelled antibodies as co-reactants

Gold nanoparticles (AuNPs) and AuNP-labelled antibodies can participate in the electrochemiluminescence (ECL) reaction of tris(2,2′-bipyridyl) ruthenium(ii) (Ru(bpy)(3)(2+)) as a co-reactant. The electrochemical and spectral characteristics of this new ECL system were confirmed by experiments, and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Changzhi, Niu, Lulu, Wang, Xiaoyu, Sun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092227/
https://www.ncbi.nlm.nih.gov/pubmed/35558472
http://dx.doi.org/10.1039/c8ra07429a
Descripción
Sumario:Gold nanoparticles (AuNPs) and AuNP-labelled antibodies can participate in the electrochemiluminescence (ECL) reaction of tris(2,2′-bipyridyl) ruthenium(ii) (Ru(bpy)(3)(2+)) as a co-reactant. The electrochemical and spectral characteristics of this new ECL system were confirmed by experiments, and its reaction mechanism was speculated to be different from that of typical ECL. The experimental results showed that the new ECL system exhibited higher ECL efficiency, and AuNP-labelled substances can be sensitively measured with the help of AuNPs. Based on the dual role of AuNPs as a co-reactant and marker, the AuNP–Ru(bpy)(3)(2+) ECL system will be a useful tool in biochemical analysis.

Ejemplares similares