Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas

This work demonstrates the safety and feasibility of Lattice Radiotherapy (LRT) for large soft tissue sarcoma in neoadjuvant radiotherapy. The treatment consisted of two courses: the LRT course with a single fraction of 20 Gy delivered to high dose nuclei (HDN) regions and the conventional course wi...

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Detalles Bibliográficos
Autores principales: Borzov, Egor, Bar-Deroma, Raquel, Lutsyk, Myroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092247/
https://www.ncbi.nlm.nih.gov/pubmed/35572042
http://dx.doi.org/10.1016/j.phro.2022.04.010
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author Borzov, Egor
Bar-Deroma, Raquel
Lutsyk, Myroslav
author_facet Borzov, Egor
Bar-Deroma, Raquel
Lutsyk, Myroslav
author_sort Borzov, Egor
collection PubMed
description This work demonstrates the safety and feasibility of Lattice Radiotherapy (LRT) for large soft tissue sarcoma in neoadjuvant radiotherapy. The treatment consisted of two courses: the LRT course with a single fraction of 20 Gy delivered to high dose nuclei (HDN) regions and the conventional course with 25 fractions of 2 Gy delivered to the planning target volume. HDN shaped as cylinders with a 1 cm diameter and 1 cm height were placed within the gross tumour volume. The number of HDNs and their position were determined based on tumor size and proximity to organs at risk. Three patients were irradiated using the LRT technique.
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spelling pubmed-90922472022-05-12 Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas Borzov, Egor Bar-Deroma, Raquel Lutsyk, Myroslav Phys Imaging Radiat Oncol Technical Note This work demonstrates the safety and feasibility of Lattice Radiotherapy (LRT) for large soft tissue sarcoma in neoadjuvant radiotherapy. The treatment consisted of two courses: the LRT course with a single fraction of 20 Gy delivered to high dose nuclei (HDN) regions and the conventional course with 25 fractions of 2 Gy delivered to the planning target volume. HDN shaped as cylinders with a 1 cm diameter and 1 cm height were placed within the gross tumour volume. The number of HDNs and their position were determined based on tumor size and proximity to organs at risk. Three patients were irradiated using the LRT technique. Elsevier 2022-05-04 /pmc/articles/PMC9092247/ /pubmed/35572042 http://dx.doi.org/10.1016/j.phro.2022.04.010 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Borzov, Egor
Bar-Deroma, Raquel
Lutsyk, Myroslav
Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title_full Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title_fullStr Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title_full_unstemmed Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title_short Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
title_sort physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092247/
https://www.ncbi.nlm.nih.gov/pubmed/35572042
http://dx.doi.org/10.1016/j.phro.2022.04.010
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