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Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study

OBJECTIVES: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). BACKGROUND: Power-controlled RF ablation is a wi...

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Autores principales: Heeger, Christian-Hendrik, Popescu, Sorin S., Kirstein, Bettina, Hatahet, Sascha, Traub, Anna, Phan, Huong-Lan, Feher, Marcel, D́Ambrosio, Gabriele, Keelani, Ahmad, Schlüter, Michael, Vogler, Julia, Eitel, Charlotte, Kuck, Karl-Heinz, Tilz, Roland R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092262/
https://www.ncbi.nlm.nih.gov/pubmed/35573650
http://dx.doi.org/10.1016/j.ijcha.2022.101042
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author Heeger, Christian-Hendrik
Popescu, Sorin S.
Kirstein, Bettina
Hatahet, Sascha
Traub, Anna
Phan, Huong-Lan
Feher, Marcel
D́Ambrosio, Gabriele
Keelani, Ahmad
Schlüter, Michael
Vogler, Julia
Eitel, Charlotte
Kuck, Karl-Heinz
Tilz, Roland R.
author_facet Heeger, Christian-Hendrik
Popescu, Sorin S.
Kirstein, Bettina
Hatahet, Sascha
Traub, Anna
Phan, Huong-Lan
Feher, Marcel
D́Ambrosio, Gabriele
Keelani, Ahmad
Schlüter, Michael
Vogler, Julia
Eitel, Charlotte
Kuck, Karl-Heinz
Tilz, Roland R.
author_sort Heeger, Christian-Hendrik
collection PubMed
description OBJECTIVES: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). BACKGROUND: Power-controlled RF ablation is a widely used technique for the treatment of premature ventricular contractions (PVCs). A novel ablation catheter offers three microelectrodes and six thermocouples at its tip and provides temperature-controlled vHP-SD (90 Watts/4 s,) with the opportunity to switch to moderate-power mode. METHODS: In this pilot study, twenty-four consecutive, prospectively enrolled patients underwent PVC ablation utilizing the vHP-SD ablation (study group) and were compared with 24 consecutive patients previously treated with power-controlled ablation (control group). Each group included 12 patients with PVCs originating from the right ventricular OT (RVOT) and 12 patients with PVCs originating from the left ventricular OT (LVOT). The acute endpoint was PVC elimination and was achieved in all patients. RESULTS: In 16/24 (67%) patients (study group) it was achieved by using vHP-SD only. The median RF delivery time was 52 (interquartile range [IQR] 16, 156) seconds (study group) and 350 (IQR 240, 442) seconds (control group, p < 0.0001). No difference was observed regarding procedure duration (p = 0.489) as well as 6-months follow-up (p = 0.712). One (4%, study group) and 2 (8%, control group) severe adverse events occured (p = 0.551). CONCLUSION: In this study, vHP-SD PVC ablation was similarly effective and safe as compared to conventional power-controlled ablation. The RF time was significantly shorter.
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spelling pubmed-90922622022-05-12 Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study Heeger, Christian-Hendrik Popescu, Sorin S. Kirstein, Bettina Hatahet, Sascha Traub, Anna Phan, Huong-Lan Feher, Marcel D́Ambrosio, Gabriele Keelani, Ahmad Schlüter, Michael Vogler, Julia Eitel, Charlotte Kuck, Karl-Heinz Tilz, Roland R. Int J Cardiol Heart Vasc Original Paper OBJECTIVES: We sought to assess the efficacy, safety and short-term clinical outcome of very high-power short-duration (vHP-SD) radiofrequency (RF) catheter ablation for the treatment of idiopathic PVCs originating from the cardiac outflow tract (OT). BACKGROUND: Power-controlled RF ablation is a widely used technique for the treatment of premature ventricular contractions (PVCs). A novel ablation catheter offers three microelectrodes and six thermocouples at its tip and provides temperature-controlled vHP-SD (90 Watts/4 s,) with the opportunity to switch to moderate-power mode. METHODS: In this pilot study, twenty-four consecutive, prospectively enrolled patients underwent PVC ablation utilizing the vHP-SD ablation (study group) and were compared with 24 consecutive patients previously treated with power-controlled ablation (control group). Each group included 12 patients with PVCs originating from the right ventricular OT (RVOT) and 12 patients with PVCs originating from the left ventricular OT (LVOT). The acute endpoint was PVC elimination and was achieved in all patients. RESULTS: In 16/24 (67%) patients (study group) it was achieved by using vHP-SD only. The median RF delivery time was 52 (interquartile range [IQR] 16, 156) seconds (study group) and 350 (IQR 240, 442) seconds (control group, p < 0.0001). No difference was observed regarding procedure duration (p = 0.489) as well as 6-months follow-up (p = 0.712). One (4%, study group) and 2 (8%, control group) severe adverse events occured (p = 0.551). CONCLUSION: In this study, vHP-SD PVC ablation was similarly effective and safe as compared to conventional power-controlled ablation. The RF time was significantly shorter. Elsevier 2022-05-04 /pmc/articles/PMC9092262/ /pubmed/35573650 http://dx.doi.org/10.1016/j.ijcha.2022.101042 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
Heeger, Christian-Hendrik
Popescu, Sorin S.
Kirstein, Bettina
Hatahet, Sascha
Traub, Anna
Phan, Huong-Lan
Feher, Marcel
D́Ambrosio, Gabriele
Keelani, Ahmad
Schlüter, Michael
Vogler, Julia
Eitel, Charlotte
Kuck, Karl-Heinz
Tilz, Roland R.
Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title_full Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title_fullStr Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title_full_unstemmed Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title_short Very-high-power short-duration ablation for treatment of premature ventricular contractions – The FAST-AND-FURIOUS PVC study
title_sort very-high-power short-duration ablation for treatment of premature ventricular contractions – the fast-and-furious pvc study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092262/
https://www.ncbi.nlm.nih.gov/pubmed/35573650
http://dx.doi.org/10.1016/j.ijcha.2022.101042
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