Single-cell analysis reveals selection of TP53-mutated clones after MDM2 inhibition

The mechanisms of transformation of chronic myeloproliferative neoplasms (MPN) to leukemia are largely unknown, but TP53 mutations acquisition is considered a key event in this process. p53 is a main tumor suppressor, but mutations in this protein per se do not confer a proliferative advantage to th...

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Detalles Bibliográficos
Autores principales: Maslah, Nabih, Verger, Emmanuelle, Giraudier, Stéphane, Chea, Mathias, Hoffman, Ronald, Mascarenhas, John, Cassinat, Bruno, Kiladjian, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092407/
https://www.ncbi.nlm.nih.gov/pubmed/35030630
http://dx.doi.org/10.1182/bloodadvances.2021005867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092407/
https://www.ncbi.nlm.nih.gov/pubmed/35030630
http://dx.doi.org/10.1182/bloodadvances.2021005867

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