Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation

Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein–protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 intera...

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Detalles Bibliográficos
Autores principales: Srdanović, Sonja, Hegedüs, Zsofia, Warriner, Stuart L., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092428/
https://www.ncbi.nlm.nih.gov/pubmed/35656480
http://dx.doi.org/10.1039/d2cb00025c
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author Srdanović, Sonja
Hegedüs, Zsofia
Warriner, Stuart L.
Wilson, Andrew J.
author_facet Srdanović, Sonja
Hegedüs, Zsofia
Warriner, Stuart L.
Wilson, Andrew J.
author_sort Srdanović, Sonja
collection PubMed
description Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein–protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction.
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spelling pubmed-90924282022-06-01 Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation Srdanović, Sonja Hegedüs, Zsofia Warriner, Stuart L. Wilson, Andrew J. RSC Chem Biol Chemistry Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein–protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction. RSC 2022-04-01 /pmc/articles/PMC9092428/ /pubmed/35656480 http://dx.doi.org/10.1039/d2cb00025c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Srdanović, Sonja
Hegedüs, Zsofia
Warriner, Stuart L.
Wilson, Andrew J.
Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title_full Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title_fullStr Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title_full_unstemmed Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title_short Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
title_sort towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092428/
https://www.ncbi.nlm.nih.gov/pubmed/35656480
http://dx.doi.org/10.1039/d2cb00025c
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