Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds

A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been...

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Detalles Bibliográficos
Autores principales: Murthy, V. Narayana, Nikumbh, Satish P., Tadiparthi, Krishnaji, Madhubabu, M. V., Jammula, Subba Rao, Rao, L. Vaikunta, Raghunadh, Akula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092434/
https://www.ncbi.nlm.nih.gov/pubmed/35558548
http://dx.doi.org/10.1039/c8ra03308k
Descripción
Sumario:A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been checked on a large scale and the possible reaction mechanism has also been proposed.

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