Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms

Several 2-arylcinnolin-6(2H)-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors a...

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Autores principales: Al-Matar, Hamad M., Dawood, Kamal M., Tohamy, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092474/
https://www.ncbi.nlm.nih.gov/pubmed/35558141
http://dx.doi.org/10.1039/c8ra06494f
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author Al-Matar, Hamad M.
Dawood, Kamal M.
Tohamy, Wael M.
author_facet Al-Matar, Hamad M.
Dawood, Kamal M.
Tohamy, Wael M.
author_sort Al-Matar, Hamad M.
collection PubMed
description Several 2-arylcinnolin-6(2H)-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors affecting the optimization of the annulation process were thoroughly studied. The annulated structures were established on the basis of (1)H and (13)C NMR and MALDI-TOF/MS spectral data as well as single crystal X-ray analysis.
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spelling pubmed-90924742022-05-11 Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms Al-Matar, Hamad M. Dawood, Kamal M. Tohamy, Wael M. RSC Adv Chemistry Several 2-arylcinnolin-6(2H)-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors affecting the optimization of the annulation process were thoroughly studied. The annulated structures were established on the basis of (1)H and (13)C NMR and MALDI-TOF/MS spectral data as well as single crystal X-ray analysis. The Royal Society of Chemistry 2018-10-08 /pmc/articles/PMC9092474/ /pubmed/35558141 http://dx.doi.org/10.1039/c8ra06494f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Al-Matar, Hamad M.
Dawood, Kamal M.
Tohamy, Wael M.
Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title_full Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title_fullStr Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title_full_unstemmed Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title_short Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
title_sort tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092474/
https://www.ncbi.nlm.nih.gov/pubmed/35558141
http://dx.doi.org/10.1039/c8ra06494f
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