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Degraders: The Ultimate Weapon Against Amplified Driver Kinases in Cancer

Amplification of pro-oncogenic kinases is a common genetic alteration driving tumorigenic phenotypes. Cancer cells rely on the amplified kinases to sustain cell proliferation, survival, and growth, presenting an opportunity to develop therapies targeting the amplified kinases. Utilizing small molecu...

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Detalles Bibliográficos
Autores principales:	Torres-Ayuso, Pedro, Brognard, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:	Axelrod Symposium Protein Kinases in Tune - Special Section
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092480/ https://www.ncbi.nlm.nih.gov/pubmed/35115411 http://dx.doi.org/10.1124/molpharm.121.000306

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