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Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for health...

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Autores principales: Khuayjarernpanishk, Thanut, Sookying, Sontaya, Duangjai, Acharaporn, Saokaew, Surasak, Sanbua, Asawadech, Bunteong, Orapa, Rungruangsri, Nutnicha, Suepsai, Witchuda, Sodsai, Patinya, Soylaiad, Jiraporn, Nacharoen, Varintorn, Noidamnoen, Suwanna, Phisalprapa, Pochamana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092523/
https://www.ncbi.nlm.nih.gov/pubmed/35571080
http://dx.doi.org/10.3389/fphar.2022.875016
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author Khuayjarernpanishk, Thanut
Sookying, Sontaya
Duangjai, Acharaporn
Saokaew, Surasak
Sanbua, Asawadech
Bunteong, Orapa
Rungruangsri, Nutnicha
Suepsai, Witchuda
Sodsai, Patinya
Soylaiad, Jiraporn
Nacharoen, Varintorn
Noidamnoen, Suwanna
Phisalprapa, Pochamana
author_facet Khuayjarernpanishk, Thanut
Sookying, Sontaya
Duangjai, Acharaporn
Saokaew, Surasak
Sanbua, Asawadech
Bunteong, Orapa
Rungruangsri, Nutnicha
Suepsai, Witchuda
Sodsai, Patinya
Soylaiad, Jiraporn
Nacharoen, Varintorn
Noidamnoen, Suwanna
Phisalprapa, Pochamana
author_sort Khuayjarernpanishk, Thanut
collection PubMed
description Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for healthcare personnel and patients alike. P. odoratum (Polygonaceae family) is a plant used as a culinary ingredient. It exhibits several pharmacological activities, such as antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer. Several classes of phytochemical constituents of P. odoratum have been reported. The important ones might be polyphenol and flavonoid derivatives. In this systematic review, the activities of P. odoratum against cancerous cells were determined and summarized. Data were obtained through a systematic search of electronic databases (EMBASE, PubMed, Scopus, Thai Thesis Database, Science Direct and Clinical Key). Eight studies met the eligibility criteria. The cancerous cell lines used in the studies were lymphoma, leukemia, oral, lung, breast, colon, and liver cancer cells. Based on this review, P. odoratum extracts significantly affected Epstein-Barr virus (EBV) genome-carrying human lymphoblastoid (Raji), mouse lymphocytic leukemia (P388), human acute lymphocytic leukemia (Jurkat), breast adenocarcinoma (MCF-7), human colon adenocarcinoma (HT-29), human T lymphoblast (MOLT-4), human promyelocytic leukemia cell line (HL-60), human hepatocellular carcinoma (HepG2), and oral squamous cell carcinoma (SAS, SCC-9, HSC-3) through induction of cell apoptosis, arrest of the cell cycle, inhibition of cell proliferation, migration, and colonization. The molecular mechanism of P. odoratum against cancers was reported to involve suppressing essential proteins required for cell proliferation, colonization, migration, apoptosis, and angiogenesis. They were survivin, cyclin-D, cyclooxygenase 2 (COX-2), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor A (VEGF-A). The extract of P. odoratum was also involved in the protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway by inhibiting the expression of Akt, phosphorylated Akt, mTOR, and phosphorylated mTOR. From the key results of this review, P. odoratum is a promising chemotherapy and chemopreventive agent. Further investigation of its pharmacological activity and mechanism of action should be conducted using standardized extracts. In vivo experiments and clinical trials are required to confirm the anticancer activity.
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spelling pubmed-90925232022-05-12 Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review Khuayjarernpanishk, Thanut Sookying, Sontaya Duangjai, Acharaporn Saokaew, Surasak Sanbua, Asawadech Bunteong, Orapa Rungruangsri, Nutnicha Suepsai, Witchuda Sodsai, Patinya Soylaiad, Jiraporn Nacharoen, Varintorn Noidamnoen, Suwanna Phisalprapa, Pochamana Front Pharmacol Pharmacology Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for healthcare personnel and patients alike. P. odoratum (Polygonaceae family) is a plant used as a culinary ingredient. It exhibits several pharmacological activities, such as antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer. Several classes of phytochemical constituents of P. odoratum have been reported. The important ones might be polyphenol and flavonoid derivatives. In this systematic review, the activities of P. odoratum against cancerous cells were determined and summarized. Data were obtained through a systematic search of electronic databases (EMBASE, PubMed, Scopus, Thai Thesis Database, Science Direct and Clinical Key). Eight studies met the eligibility criteria. The cancerous cell lines used in the studies were lymphoma, leukemia, oral, lung, breast, colon, and liver cancer cells. Based on this review, P. odoratum extracts significantly affected Epstein-Barr virus (EBV) genome-carrying human lymphoblastoid (Raji), mouse lymphocytic leukemia (P388), human acute lymphocytic leukemia (Jurkat), breast adenocarcinoma (MCF-7), human colon adenocarcinoma (HT-29), human T lymphoblast (MOLT-4), human promyelocytic leukemia cell line (HL-60), human hepatocellular carcinoma (HepG2), and oral squamous cell carcinoma (SAS, SCC-9, HSC-3) through induction of cell apoptosis, arrest of the cell cycle, inhibition of cell proliferation, migration, and colonization. The molecular mechanism of P. odoratum against cancers was reported to involve suppressing essential proteins required for cell proliferation, colonization, migration, apoptosis, and angiogenesis. They were survivin, cyclin-D, cyclooxygenase 2 (COX-2), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor A (VEGF-A). The extract of P. odoratum was also involved in the protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway by inhibiting the expression of Akt, phosphorylated Akt, mTOR, and phosphorylated mTOR. From the key results of this review, P. odoratum is a promising chemotherapy and chemopreventive agent. Further investigation of its pharmacological activity and mechanism of action should be conducted using standardized extracts. In vivo experiments and clinical trials are required to confirm the anticancer activity. Frontiers Media S.A. 2022-04-27 /pmc/articles/PMC9092523/ /pubmed/35571080 http://dx.doi.org/10.3389/fphar.2022.875016 Text en Copyright © 2022 Khuayjarernpanishk, Sookying, Duangjai, Saokaew, Sanbua, Bunteong, Rungruangsri, Suepsai, Sodsai, Soylaiad, Nacharoen, Noidamnoen and Phisalprapa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Khuayjarernpanishk, Thanut
Sookying, Sontaya
Duangjai, Acharaporn
Saokaew, Surasak
Sanbua, Asawadech
Bunteong, Orapa
Rungruangsri, Nutnicha
Suepsai, Witchuda
Sodsai, Patinya
Soylaiad, Jiraporn
Nacharoen, Varintorn
Noidamnoen, Suwanna
Phisalprapa, Pochamana
Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title_full Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title_fullStr Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title_full_unstemmed Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title_short Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review
title_sort anticancer activities of polygonum odoratum lour.: a systematic review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092523/
https://www.ncbi.nlm.nih.gov/pubmed/35571080
http://dx.doi.org/10.3389/fphar.2022.875016
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