Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles

The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene (TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission (AIE) active TPE units allow monitoring the assembly process by fluorescence spectroscopy. The number of TPE modification...

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Detalles Bibliográficos
Autores principales: Rothenbühler, Simon, Gonzalez, Adrian, Iacovache, Ioan, Langenegger, Simon M., Zuber, Benoît, Häner, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092531/
https://www.ncbi.nlm.nih.gov/pubmed/35262542
http://dx.doi.org/10.1039/d2ob00357k
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author Rothenbühler, Simon
Gonzalez, Adrian
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
author_facet Rothenbühler, Simon
Gonzalez, Adrian
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
author_sort Rothenbühler, Simon
collection PubMed
description The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene (TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission (AIE) active TPE units allow monitoring the assembly process by fluorescence spectroscopy. The number of TPE modifications in the overhangs of the conjugates influences the supramolecular assembly behavior. A minimum of two TPE residues on each end are required to ensure a well-defined assembly process. The design of the presented DNA-based nanostructures offers tailored functionalization with applications in DNA nanotechnology.
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spelling pubmed-90925312022-06-01 Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles Rothenbühler, Simon Gonzalez, Adrian Iacovache, Ioan Langenegger, Simon M. Zuber, Benoît Häner, Robert Org Biomol Chem Chemistry The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene (TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission (AIE) active TPE units allow monitoring the assembly process by fluorescence spectroscopy. The number of TPE modifications in the overhangs of the conjugates influences the supramolecular assembly behavior. A minimum of two TPE residues on each end are required to ensure a well-defined assembly process. The design of the presented DNA-based nanostructures offers tailored functionalization with applications in DNA nanotechnology. The Royal Society of Chemistry 2022-03-04 /pmc/articles/PMC9092531/ /pubmed/35262542 http://dx.doi.org/10.1039/d2ob00357k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Rothenbühler, Simon
Gonzalez, Adrian
Iacovache, Ioan
Langenegger, Simon M.
Zuber, Benoît
Häner, Robert
Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title_full Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title_fullStr Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title_full_unstemmed Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title_short Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles
title_sort tetraphenylethylene–dna conjugates: influence of sticky ends and dna sequence length on the supramolecular assembly of aie-active vesicles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092531/
https://www.ncbi.nlm.nih.gov/pubmed/35262542
http://dx.doi.org/10.1039/d2ob00357k
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