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A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data
INTRODUCTION: This study aimed to develop and validate a 3‐year dementia risk score in individuals with mild cognitive impairment (MCI) based on variables collected in routine clinical care. METHODS: The prediction score was trained and developed using data from the National Alzheimer's Coordin...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092734/ https://www.ncbi.nlm.nih.gov/pubmed/35592692 http://dx.doi.org/10.1002/trc2.12301 |
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author | Wang, Meng Sajobi, Tolulope T. Ismail, Zahinoor Seitz, Dallas Chekouo, Thierry Forkert, Nils D. Fischer, Karyn Mackie, Aaron Pearson, Dawn Patry, David Cieslak, Alicja Menon, Bijoy Barber, Philip McLane, Brienne Granger, Robert Hogan, David B. Smith, Eric E. |
author_facet | Wang, Meng Sajobi, Tolulope T. Ismail, Zahinoor Seitz, Dallas Chekouo, Thierry Forkert, Nils D. Fischer, Karyn Mackie, Aaron Pearson, Dawn Patry, David Cieslak, Alicja Menon, Bijoy Barber, Philip McLane, Brienne Granger, Robert Hogan, David B. Smith, Eric E. |
author_sort | Wang, Meng |
collection | PubMed |
description | INTRODUCTION: This study aimed to develop and validate a 3‐year dementia risk score in individuals with mild cognitive impairment (MCI) based on variables collected in routine clinical care. METHODS: The prediction score was trained and developed using data from the National Alzheimer's Coordinating Center (NACC). Selection criteria included aged 55 years and older with MCI. Cox models were validated externally using two independent cohorts from the Prospective Registry of Persons with Memory Symptoms (PROMPT) registry and the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. RESULTS: Our Mild Cognitive Impairment to Dementia Risk (CIDER) score predicted dementia risk with c‐indices of 0.69 (95% confidence interval [CI] 0.66–0.72), 0.61 (95% CI 0.59–0.63), and 0.72 (95% CI 0.69–0.75), for the internally validated and the external validation PROMPT, and ADNI cohorts, respectively. DISCUSSION: The CIDER score could be used to inform clinicians and patients about the relative probabilities of developing dementia in patients with MCI. |
format | Online Article Text |
id | pubmed-9092734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90927342022-05-18 A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data Wang, Meng Sajobi, Tolulope T. Ismail, Zahinoor Seitz, Dallas Chekouo, Thierry Forkert, Nils D. Fischer, Karyn Mackie, Aaron Pearson, Dawn Patry, David Cieslak, Alicja Menon, Bijoy Barber, Philip McLane, Brienne Granger, Robert Hogan, David B. Smith, Eric E. Alzheimers Dement (N Y) Research Articles INTRODUCTION: This study aimed to develop and validate a 3‐year dementia risk score in individuals with mild cognitive impairment (MCI) based on variables collected in routine clinical care. METHODS: The prediction score was trained and developed using data from the National Alzheimer's Coordinating Center (NACC). Selection criteria included aged 55 years and older with MCI. Cox models were validated externally using two independent cohorts from the Prospective Registry of Persons with Memory Symptoms (PROMPT) registry and the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. RESULTS: Our Mild Cognitive Impairment to Dementia Risk (CIDER) score predicted dementia risk with c‐indices of 0.69 (95% confidence interval [CI] 0.66–0.72), 0.61 (95% CI 0.59–0.63), and 0.72 (95% CI 0.69–0.75), for the internally validated and the external validation PROMPT, and ADNI cohorts, respectively. DISCUSSION: The CIDER score could be used to inform clinicians and patients about the relative probabilities of developing dementia in patients with MCI. John Wiley and Sons Inc. 2022-05-11 /pmc/articles/PMC9092734/ /pubmed/35592692 http://dx.doi.org/10.1002/trc2.12301 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Wang, Meng Sajobi, Tolulope T. Ismail, Zahinoor Seitz, Dallas Chekouo, Thierry Forkert, Nils D. Fischer, Karyn Mackie, Aaron Pearson, Dawn Patry, David Cieslak, Alicja Menon, Bijoy Barber, Philip McLane, Brienne Granger, Robert Hogan, David B. Smith, Eric E. A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title | A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title_full | A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title_fullStr | A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title_full_unstemmed | A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title_short | A pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: Development and validation of a dementia risk score using routinely collected data |
title_sort | pragmatic dementia risk score for patients with mild cognitive impairment in a memory clinic population: development and validation of a dementia risk score using routinely collected data |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092734/ https://www.ncbi.nlm.nih.gov/pubmed/35592692 http://dx.doi.org/10.1002/trc2.12301 |
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