Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells

BACKGROUND: Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) signaling improves DN. Although LPA signaling is implicated in diabetic renal fib...

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Detalles Bibliográficos
Autores principales: Kim, Donghee, Nam, Ga-Young, Seo, Eunhui, Jun, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092836/
https://www.ncbi.nlm.nih.gov/pubmed/35538534
http://dx.doi.org/10.1186/s12929-022-00814-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092836/
https://www.ncbi.nlm.nih.gov/pubmed/35538534
http://dx.doi.org/10.1186/s12929-022-00814-1

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