Cargando…

Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells

BACKGROUND: Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) signaling improves DN. Although LPA signaling is implicated in diabetic renal fib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Donghee, Nam, Ga-Young, Seo, Eunhui, Jun, Hee-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092836/ https://www.ncbi.nlm.nih.gov/pubmed/35538534 http://dx.doi.org/10.1186/s12929-022-00814-1

Ejemplares similares

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
por: Jung, Hunmin, et al.
Publicado: (2020)

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression
por: Jeong, Yun-Seung, et al.
Publicado: (2011)

Carbohydrate Sensing Through the Transcription Factor ChREBP
por: Ortega-Prieto, Paula, et al.
Publicado: (2019)

Carbohydrate response element binding protein (ChREBP) modulates the inflammatory response of mesangial cells in response to glucose
por: Chen, Yan, et al.
Publicado: (2018)

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop
por: Jing, Gu, et al.
Publicado: (2016)

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets
por: Katz, Liora S., et al.
Publicado: (2021)

New insights into the inter-organ crosstalk mediated by ChREBP
por: Carbinatti, Thais, et al.
Publicado: (2023)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing
por: Benhamed, Fadila, et al.
Publicado: (2015)

ChREBP Rather Than SHP Regulates Hepatic VLDL Secretion
por: Niwa, Hiroyuki, et al.
Publicado: (2018)

ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption
por: Kato, Takehiro, et al.
Publicado: (2018)

Retinol saturase coordinates liver metabolism by regulating ChREBP activity
por: Heidenreich, Steffi, et al.
Publicado: (2017)

Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression
por: Spalletta, Sonia, et al.
Publicado: (2018)

Recent insights into the role of ChREBP in intestinal fructose absorption and metabolism
por: Lee, Ho-Jae, et al.
Publicado: (2018)

ChREBP-regulated lipogenesis is not required for the thermogenesis of brown adipose tissue
por: Wei, Chunchun, et al.
Publicado: (2022)

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance
por: Recazens, Emeline, et al.
Publicado: (2022)

ChREBP Reciprocally Regulates Liver and Plasma Triacylglycerol Levels in Different Manners
por: Iizuka, Katsumi, et al.
Publicado: (2018)

Dual regulation of TxNIP by ChREBP and FoxO1 in liver
por: Noblet, Benedicte, et al.
Publicado: (2021)

The Function of MondoA and ChREBP Nutrient—Sensing Factors in Metabolic Disease
por: Ahn, Byungyong
Publicado: (2023)

HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis
por: Sargsyan, Ashot, et al.
Publicado: (2023)

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
por: Guinez, Céline, et al.
Publicado: (2011)

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
por: Herman, Mark A., et al.
Publicado: (2012)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice
por: Jois, Tara, et al.
Publicado: (2016)

The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice
por: Rajas, Fabienne, et al.
Publicado: (2020)

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells
por: da Silva Xavier, Gabriela, et al.
Publicado: (2010)

Mondo/ChREBP-Mlx-Regulated Transcriptional Network Is Essential for Dietary Sugar Tolerance in Drosophila
por: Havula, Essi, et al.
Publicado: (2013)

ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β–Cell Line
por: Sae-Lee, Chanachai, et al.
Publicado: (2016)

Associations of ChREBP and Global DNA Methylation with Genetic and Environmental Factors in Chinese Healthy Adults
por: Gao, Jiajia, et al.
Publicado: (2016)

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
por: Fisher, ffolliott M., et al.
Publicado: (2016)

ChREBP-Mediated Regulation of Lipid Metabolism: Involvement of the Gut Microbiota, Liver, and Adipose Tissue
por: Iizuka, Katsumi, et al.
Publicado: (2020)

Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
por: Katz, Liora S., et al.
Publicado: (2022)

Effects of low-carbohydrate diet therapy in overweight subjects with autoimmune thyroiditis: possible synergism with ChREBP
por: Esposito, Teresa, et al.
Publicado: (2016)

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice
por: Linden, Albert G., et al.
Publicado: (2018)

ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression
por: Sakiyama, Haruhiko, et al.
Publicado: (2022)

The transcription factor ChREBP links mitochondrial lipidomes to mitochondrial morphology and progression of diabetic kidney disease
por: Li, Li, et al.
Publicado: (2023)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose
por: Meng, Jian, et al.
Publicado: (2016)

ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways
por: Zeng, Hongxiang, et al.
Publicado: (2016)

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation
por: Kumar, Anil, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bgsohv90i5l8cnlpt7hn29ffjk