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Inflammatory cytokine profile and T cell responses in African tick bite fever patients
African tick bite fever, an acute febrile illness, is caused by the obligate intracellular bacterium Rickettsia africae. Immune responses to rickettsial infections have so far mainly been investigated in vitro with infected endothelial cells as the main target cells, and in mouse models. Patient stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092931/ https://www.ncbi.nlm.nih.gov/pubmed/35543881 http://dx.doi.org/10.1007/s00430-022-00738-5 |
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author | Rauch, Jessica Jochum, Johannes Eisermann, Philip Gisbrecht, Jana Völker, Katrin Hunstig, Friederike Mehlhoop, Ute Muntau, Birgit Tappe, Dennis |
author_facet | Rauch, Jessica Jochum, Johannes Eisermann, Philip Gisbrecht, Jana Völker, Katrin Hunstig, Friederike Mehlhoop, Ute Muntau, Birgit Tappe, Dennis |
author_sort | Rauch, Jessica |
collection | PubMed |
description | African tick bite fever, an acute febrile illness, is caused by the obligate intracellular bacterium Rickettsia africae. Immune responses to rickettsial infections have so far mainly been investigated in vitro with infected endothelial cells as the main target cells, and in mouse models. Patient studies are rare and little is known about the immunology of human infections. In this study, inflammatory mediators and T cell responses were examined in samples from 13 patients with polymerase chain reaction-confirmed R. africae infections at different time points of illness. The Th1-associated cytokines IFNγ and IL-12 were increased in the acute phase of illness, as were levels of the T cell chemoattractant cytokine CXCL-10. In addition, the anti-inflammatory cytokine IL-10 and also IL-22 were elevated. IL-22 but not IFNγ was increasingly produced by CD4(+) and CD8(+) T cells during illness. Besides IFNγ, IL-22 appears to play a protective role in rickettsial infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00430-022-00738-5. |
format | Online Article Text |
id | pubmed-9092931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-90929312022-05-12 Inflammatory cytokine profile and T cell responses in African tick bite fever patients Rauch, Jessica Jochum, Johannes Eisermann, Philip Gisbrecht, Jana Völker, Katrin Hunstig, Friederike Mehlhoop, Ute Muntau, Birgit Tappe, Dennis Med Microbiol Immunol Original Investigation African tick bite fever, an acute febrile illness, is caused by the obligate intracellular bacterium Rickettsia africae. Immune responses to rickettsial infections have so far mainly been investigated in vitro with infected endothelial cells as the main target cells, and in mouse models. Patient studies are rare and little is known about the immunology of human infections. In this study, inflammatory mediators and T cell responses were examined in samples from 13 patients with polymerase chain reaction-confirmed R. africae infections at different time points of illness. The Th1-associated cytokines IFNγ and IL-12 were increased in the acute phase of illness, as were levels of the T cell chemoattractant cytokine CXCL-10. In addition, the anti-inflammatory cytokine IL-10 and also IL-22 were elevated. IL-22 but not IFNγ was increasingly produced by CD4(+) and CD8(+) T cells during illness. Besides IFNγ, IL-22 appears to play a protective role in rickettsial infections. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00430-022-00738-5. Springer Berlin Heidelberg 2022-05-11 2022 /pmc/articles/PMC9092931/ /pubmed/35543881 http://dx.doi.org/10.1007/s00430-022-00738-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Investigation Rauch, Jessica Jochum, Johannes Eisermann, Philip Gisbrecht, Jana Völker, Katrin Hunstig, Friederike Mehlhoop, Ute Muntau, Birgit Tappe, Dennis Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title | Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title_full | Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title_fullStr | Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title_full_unstemmed | Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title_short | Inflammatory cytokine profile and T cell responses in African tick bite fever patients |
title_sort | inflammatory cytokine profile and t cell responses in african tick bite fever patients |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092931/ https://www.ncbi.nlm.nih.gov/pubmed/35543881 http://dx.doi.org/10.1007/s00430-022-00738-5 |
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