Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1

Protein kinases are crucial drug targets in cancer therapy. Kinase inhibitors are promiscuous in nature due to the highly conserved nature of the kinase ATP binding pockets. PERK has emerged as a potential therapeutic target in cancer. However, PERK inhibitors GSK2606414 and GSK2656157 also target R...

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Detalles Bibliográficos
Autores principales: Chintha, Chetan, Carlesso, Antonio, Gorman, Adrienne M., Samali, Afshin, Eriksson, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092956/
https://www.ncbi.nlm.nih.gov/pubmed/35558862
http://dx.doi.org/10.1039/c9ra08047c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092956/
https://www.ncbi.nlm.nih.gov/pubmed/35558862
http://dx.doi.org/10.1039/c9ra08047c

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