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Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1
Protein kinases are crucial drug targets in cancer therapy. Kinase inhibitors are promiscuous in nature due to the highly conserved nature of the kinase ATP binding pockets. PERK has emerged as a potential therapeutic target in cancer. However, PERK inhibitors GSK2606414 and GSK2656157 also target R...
Autores principales: | Chintha, Chetan, Carlesso, Antonio, Gorman, Adrienne M., Samali, Afshin, Eriksson, Leif A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092956/ https://www.ncbi.nlm.nih.gov/pubmed/35558862 http://dx.doi.org/10.1039/c9ra08047c |
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