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New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein

Misfolding of the prion protein (PrP) is responsible for devastating neurological disorders in humans and other mammals. An unresolved problem in the field is unraveling the mechanisms governing PrP conformational dynamics, misfolding, and the cellular mechanism leading to neurodegeneration. The var...

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Detalles Bibliográficos
Autores principales:	Myers, Ryan R., Sanchez-Garcia, Jonatan, Leving, Daniel C., Melvin, Richard G., Fernandez-Funez, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093039/ https://www.ncbi.nlm.nih.gov/pubmed/35142350 http://dx.doi.org/10.1242/dmm.049184

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