Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain

A series of amino acid based 7H-pyrrolo[2,3–d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replication and pathogenesis. Structure activity studies id...

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Detalles Bibliográficos
Autores principales: Sherrill, Lavinia M., Joya, Elva E., Walker, AnnMarie, Roy, Anuradha, Alhammad, Yousef M., Atobatele, Moriama, Wazir, Sarah, Abbas, George, Keane, Patrick, Zhuo, Junlin, Leung, Anthony K.L., Johnson, David K., Lehtiö, Lari, Fehr, Anthony R., Ferraris, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093066/
https://www.ncbi.nlm.nih.gov/pubmed/35597097
http://dx.doi.org/10.1016/j.bmc.2022.116788

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