Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease

Increasing cases of SARS-CoV-2 breakthrough infections from immunization with current spike protein-based COVID-19 vaccines highlight the need to develop alternative vaccines using different platforms and/or antigens. In this study, we expressed SARS-CoV-2 spike and nucleocapsid proteins based on a...

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Detalles Bibliográficos
Autores principales: Deschambault, Yvon, Lynch, Jessie, Warner, Bryce, Tierney, Kevin, Huynh, Denise, Vendramelli, Robert, Tailor, Nikesh, Frost, Kathy, Sajesh, Babu, LeBlanc, Kyle, Layne, Christine, Lin, Lisa, Tamming, Levi, Beniac, Daniel, Booth, Stephanie, Carpenter, Michael, Safronetz, David, Li, Xuguang, Kobasa, Darwyn, Cao, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093096/
https://www.ncbi.nlm.nih.gov/pubmed/35412347
http://dx.doi.org/10.1128/jvi.00389-22

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