Cargando…

Single-Cell Landscape of Lungs Reveals Key Role of Neutrophil-Mediated Immunopathology during Lethal SARS-CoV-2 Infection

Due to the limitation of human studies with respect to individual difference or the accessibility of fresh tissue samples, how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in pathological complications in lung, the main site of infection, is still incompletely under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Xiao-Shuang, Wang, Qi, Min, Juan, Shen, Xu-Rui, Li, Qian, Zhao, Qiu-Chen, Wang, Xi, Jiang, Ren-Di, Geng, Rong, Chen, Ying, Zhu, Yan, Li, Bei, Zhang, Wei, Li, Ang, Xie, Ting-Ting, Liu, Mei-Qin, Cheng, Liang, Shi, Zheng-Li, Zhou, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093099/ https://www.ncbi.nlm.nih.gov/pubmed/35420442 http://dx.doi.org/10.1128/jvi.00038-22

Ejemplares similares

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection
por: Iwata-Yoshikawa, Naoko, et al.
Publicado: (2019)

The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge
por: Li, Yongfeng, et al.
Publicado: (2022)

A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice
por: Liu, Mei-Qin, et al.
Publicado: (2023)

Epstein-Barr Virus-Specific CD8 T Cells Selectively Infiltrate the Brain in Multiple Sclerosis and Interact Locally with Virus-Infected Cells: Clue for a Virus-Driven Immunopathological Mechanism
por: Serafini, Barbara, et al.
Publicado: (2019)

Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
por: Chan, Mable, et al.
Publicado: (2022)

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication
por: Liu, Hainan, et al.
Publicado: (2022)

SARS-CoV-2 Rapidly Adapts in Aged BALB/c Mice and Induces Typical Pneumonia
por: Zhang, Yufei, et al.
Publicado: (2021)

Lethal Hemorrhagic Disease and Clinical Illness Associated with Elephant Endotheliotropic Herpesvirus 1 Are Caused by Primary Infection: Implications for the Detection of Diagnostic Proteins
por: Fuery, Angela, et al.
Publicado: (2020)

Genetic Determinants of Altered Virulence of Type O Foot-and-Mouth Disease Virus
por: Yang, Fan, et al.
Publicado: (2020)

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus
por: Syage, Amber R., et al.
Publicado: (2020)

Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies
por: Mabvakure, Batsirai M., et al.
Publicado: (2019)

CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo
por: Teng, Ooiean, et al.
Publicado: (2016)

The Furin-S2′ Site in Avian Coronavirus Plays a Key Role in Central Nervous System Damage Progression
por: Cheng, Jinlong, et al.
Publicado: (2021)

PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation
por: He, Sheng, et al.
Publicado: (2022)

Transgene-Assisted Genetic Screen Identifies rsd-6 and Novel Genes as Key Components of Antiviral RNA Interference in Caenorhabditis elegans
por: Long, Tianyun, et al.
Publicado: (2018)

The African swine fever virus I10L protein inhibits the NF-κB signaling pathway by targeting IKKβ
por: Chen, Xing, et al.
Publicado: (2023)

Characterization of an Emergent Chicken H3N8 Influenza Virus in Southern China: a Potential Threat to Public Health
por: Chen, Peiwen, et al.
Publicado: (2023)

SUMO Modification of Histone Demethylase KDM4A in Kaposi’s Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma
por: Yeh, Wayne W., et al.
Publicado: (2022)

A Novel Pathway for Porcine Epidemic Diarrhea Virus Transmission from Sows to Neonatal Piglets Mediated by Colostrum
por: Yuan, Chen, et al.
Publicado: (2022)

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus
por: Li, Yuming, et al.
Publicado: (2022)

Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of the TPL2 Trimer by Degradation of TPL2 To Evade Host Antiviral Immunity
por: Zhang, Keshan, et al.
Publicado: (2021)

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge
por: Ding, Mingyang, et al.
Publicado: (2022)

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
por: Feng, Xiaoxiao, et al.
Publicado: (2016)

Combinational Deletions of MGF110-9L and MGF505-7R Genes from the African Swine Fever Virus Inhibit TBK1 Degradation by an Autophagy Activator PIK3C2B To Promote Type I Interferon Production
por: Zhu, Guoqiang, et al.
Publicado: (2023)

Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
por: Zhao, Dongming, et al.
Publicado: (2017)

Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in Mice
por: Ma, Shujie, et al.
Publicado: (2020)

Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C
por: Tartaglia, Lawrence J., et al.
Publicado: (2020)

Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks
por: Sanz-Bernardo, Beatriz, et al.
Publicado: (2021)

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection
por: Li, Yongqi, et al.
Publicado: (2023)

Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse
por: Yang, Huan, et al.
Publicado: (2023)

FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication
por: Ma, XuSheng, et al.
Publicado: (2022)

Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2-Infected Syrian Hamsters
por: Brocato, Rebecca L., et al.
Publicado: (2020)

Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine
por: Feng, Helong, et al.
Publicado: (2023)

Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein
por: Li, Yuqi, et al.
Publicado: (2022)

Immune Responses and Viral Persistence in Simian/Human Immunodeficiency Virus SHIV.C.CH848-Infected Rhesus Macaques
por: Ziani, Widade, et al.
Publicado: (2021)

A Single-Amino-Acid Substitution at Position 225 in Hemagglutinin Alters the Transmissibility of Eurasian Avian-Like H1N1 Swine Influenza Virus in Guinea Pigs
por: Wang, Zeng, et al.
Publicado: (2017)

The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus
por: Dong, Wenjuan, et al.
Publicado: (2022)

The Pseudoknot Region of the 5′ Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease Virus
por: Zhu, Zixiang, et al.
Publicado: (2019)

Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity
por: Wong, Gary, et al.
Publicado: (2018)

NK Cells Accumulate in Infected Tissues and Contribute to Pathogenicity of Ebola Virus in Mice
por: Fausther-Bovendo, H., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l6iu5b6nq6gubtavhcgbh5p92g