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Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidenc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093120/ https://www.ncbi.nlm.nih.gov/pubmed/35412348 http://dx.doi.org/10.1128/jvi.00051-22 |
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author | Pley, Caitlin Lourenço, José McNaughton, Anna L. Matthews, Philippa C. |
author_facet | Pley, Caitlin Lourenço, José McNaughton, Anna L. Matthews, Philippa C. |
author_sort | Pley, Caitlin |
collection | PubMed |
description | Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes. |
format | Online Article Text |
id | pubmed-9093120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-90931202022-05-12 Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? Pley, Caitlin Lourenço, José McNaughton, Anna L. Matthews, Philippa C. J Virol Gem Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes. American Society for Microbiology 2022-04-12 /pmc/articles/PMC9093120/ /pubmed/35412348 http://dx.doi.org/10.1128/jvi.00051-22 Text en Copyright © 2022 Pley et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Gem Pley, Caitlin Lourenço, José McNaughton, Anna L. Matthews, Philippa C. Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title | Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title_full | Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title_fullStr | Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title_full_unstemmed | Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title_short | Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? |
title_sort | spacer domain in hepatitis b virus polymerase: plugging a hole or performing a role? |
topic | Gem |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093120/ https://www.ncbi.nlm.nih.gov/pubmed/35412348 http://dx.doi.org/10.1128/jvi.00051-22 |
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