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Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?

Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidenc...

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Detalles Bibliográficos
Autores principales: Pley, Caitlin, Lourenço, José, McNaughton, Anna L., Matthews, Philippa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Gem
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093120/
https://www.ncbi.nlm.nih.gov/pubmed/35412348
http://dx.doi.org/10.1128/jvi.00051-22
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author Pley, Caitlin
Lourenço, José
McNaughton, Anna L.
Matthews, Philippa C.
author_facet Pley, Caitlin
Lourenço, José
McNaughton, Anna L.
Matthews, Philippa C.
author_sort Pley, Caitlin
collection PubMed
description Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes.
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spelling pubmed-90931202022-05-12 Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role? Pley, Caitlin Lourenço, José McNaughton, Anna L. Matthews, Philippa C. J Virol Gem Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes. American Society for Microbiology 2022-04-12 /pmc/articles/PMC9093120/ /pubmed/35412348 http://dx.doi.org/10.1128/jvi.00051-22 Text en Copyright © 2022 Pley et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Gem
Pley, Caitlin
Lourenço, José
McNaughton, Anna L.
Matthews, Philippa C.
Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title_full Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title_fullStr Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title_full_unstemmed Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title_short Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
title_sort spacer domain in hepatitis b virus polymerase: plugging a hole or performing a role?
topic Gem
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093120/
https://www.ncbi.nlm.nih.gov/pubmed/35412348
http://dx.doi.org/10.1128/jvi.00051-22
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