Energetics of a protein disorder–order transition in small molecule recognition

Many proteins recognise other proteins via mechanisms that involve the folding of intrinsically disordered regions upon complex formation. Here we investigate how the selectivity of a drug-like small molecule arises from its modulation of a protein disorder-to-order transition. Binding of the compou...

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Detalles Bibliográficos
Autores principales: Mendoza-Martinez, Cesar, Papadourakis, Michail, Llabrés, Salomé, Gupta, Arun A., Barlow, Paul N., Michel, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093188/
https://www.ncbi.nlm.nih.gov/pubmed/35655546
http://dx.doi.org/10.1039/d2sc00028h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093188/
https://www.ncbi.nlm.nih.gov/pubmed/35655546
http://dx.doi.org/10.1039/d2sc00028h

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