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Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics
An Electrical Impedance Tomography (EIT) system has been developed for dynamic three-dimensional imaging of changes in conductivity distribution in the human head, using scalp-mounted electrodes. We attribute these images to changes in cerebral perfusion. At 100 frames per second (fps), voltage meas...
Formato: | Online Artículo Texto |
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Lenguaje: | English |
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IEEE
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093315/ https://www.ncbi.nlm.nih.gov/pubmed/35673527 http://dx.doi.org/10.1109/JSEN.2022.3145587 |
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collection | PubMed |
description | An Electrical Impedance Tomography (EIT) system has been developed for dynamic three-dimensional imaging of changes in conductivity distribution in the human head, using scalp-mounted electrodes. We attribute these images to changes in cerebral perfusion. At 100 frames per second (fps), voltage measurement is achieved with full-scale signal-to-noise ratio of 105 dB and common-mode rejection ratio > 90 dB. A novel nonlinear method is presented for 3-D imaging of the difference in conductivity distribution in the head, relative to a reference time. The method achieves much reduced modelling error. It successfully localizes conductivity inclusions in experimental and simulation tests, where previous methods fail. For > 50 human volunteers, the rheoencephalography (REG) waveform is observed in EIT voltage measurements for every volunteer, with peak-to-peak amplitudes up to approx. [Formula: see text]. Images are presented of the change in conductivity distribution during the REG/cardiac cycle, at 50 fps, showing maximum local conductivity change of approx. 1% in grey/white matter. A total of 17 tests were performed during short (typically 5s) carotid artery occlusions on 5 volunteers, monitored by Transcranial Doppler ultrasound. From EIT measurements averaged over complete REG/cardiac cycles, 13 occlusion tests showed consistently decreased conductivity of cerebral regions on the occluded side, and increased conductivity on the opposite side. The maximum local conductivity change during occlusion was approx. 20%. The simplicity of the carotid artery intervention provides a striking validation of the scalp-mounted measurement system in imaging cerebral hemodynamics, and the REG images indicate its unique combination of sensitivity and temporal resolution. |
format | Online Article Text |
id | pubmed-9093315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | IEEE |
record_format | MEDLINE/PubMed |
spelling | pubmed-90933152022-06-06 Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics IEEE Sens J Article An Electrical Impedance Tomography (EIT) system has been developed for dynamic three-dimensional imaging of changes in conductivity distribution in the human head, using scalp-mounted electrodes. We attribute these images to changes in cerebral perfusion. At 100 frames per second (fps), voltage measurement is achieved with full-scale signal-to-noise ratio of 105 dB and common-mode rejection ratio > 90 dB. A novel nonlinear method is presented for 3-D imaging of the difference in conductivity distribution in the head, relative to a reference time. The method achieves much reduced modelling error. It successfully localizes conductivity inclusions in experimental and simulation tests, where previous methods fail. For > 50 human volunteers, the rheoencephalography (REG) waveform is observed in EIT voltage measurements for every volunteer, with peak-to-peak amplitudes up to approx. [Formula: see text]. Images are presented of the change in conductivity distribution during the REG/cardiac cycle, at 50 fps, showing maximum local conductivity change of approx. 1% in grey/white matter. A total of 17 tests were performed during short (typically 5s) carotid artery occlusions on 5 volunteers, monitored by Transcranial Doppler ultrasound. From EIT measurements averaged over complete REG/cardiac cycles, 13 occlusion tests showed consistently decreased conductivity of cerebral regions on the occluded side, and increased conductivity on the opposite side. The maximum local conductivity change during occlusion was approx. 20%. The simplicity of the carotid artery intervention provides a striking validation of the scalp-mounted measurement system in imaging cerebral hemodynamics, and the REG images indicate its unique combination of sensitivity and temporal resolution. IEEE 2022-01-21 /pmc/articles/PMC9093315/ /pubmed/35673527 http://dx.doi.org/10.1109/JSEN.2022.3145587 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title | Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title_full | Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title_fullStr | Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title_full_unstemmed | Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title_short | Scalp-Mounted Electrical Impedance Tomography of Cerebral Hemodynamics |
title_sort | scalp-mounted electrical impedance tomography of cerebral hemodynamics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093315/ https://www.ncbi.nlm.nih.gov/pubmed/35673527 http://dx.doi.org/10.1109/JSEN.2022.3145587 |
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