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CRISPR/Cas9-Mediated Knockout of the Dicer and Ago2 Genes in BHK-21 Cell Promoted Seneca Virus A Replication and Enhanced Autophagy

RNA interference (RNAi) is a major form of antiviral defense in host cells, and Ago2 and Dicer are the major proteins of RNAi. The Senecavirus A (SVA) is a reemerging virus, resulting in vesicular lesions in sows and a sharp decline in neonatal piglet production. In this study, CRISPR/Cas9 technolog...

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Detalles Bibliográficos
Autores principales:	Wu, Xiaoyan, Wang, Shuo, Li, Chen, Shi, Jianli, Peng, Zhe, Liu, Chang, Han, Hong, Ma, Yingru, Zheng, Limei, Xu, Shaojian, Du, Wei, Li, Jun, Zhang, Fan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093602/ https://www.ncbi.nlm.nih.gov/pubmed/35573771 http://dx.doi.org/10.3389/fcimb.2022.865744

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