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Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegans

Idiopathic Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic (DA) neurons during aging. The pathological hallmark of PD is the Lewy body detected in postmortem brain tissue, which is mainly composed of aggregated α-Synuclein (αSyn). However, it is estimated that 90% of PD...

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Detalles Bibliográficos
Autores principales:	Vozdek, Roman, Pramstaller, Peter P., Hicks, Andrew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093606/ https://www.ncbi.nlm.nih.gov/pubmed/35572147 http://dx.doi.org/10.3389/fnagi.2022.806000

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