Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular mechanisms connecting APOE4 to AD are not well und...

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Detalles Bibliográficos
Autores principales: Belonwu, Stella A., Li, Yaqiao, Bunis, Daniel G., Rao, Arjun Arkal, Solsberg, Caroline Warly, Oskotsky, Tomiko, Taubes, Alice L., Grone, Brian, Zalocusky, Kelly A., Fragiadakis, Gabriela K., Huang, Yadong, Sirota, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093608/
https://www.ncbi.nlm.nih.gov/pubmed/35572130
http://dx.doi.org/10.3389/fnagi.2022.749991

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