HPV51-associated Leiomyosarcoma: A Novel Class of TP53/RB1-Wildtype Tumor With Predilection for the Female Lower Reproductive Tract

Inactivating mutations in tumor suppressor genes TP53 and RB1 are considered central drivers in leiomyosarcomas (LMSs). In high-risk human papillomavirus (HPV)-related tumors, a similar functional outcome is achieved through oncoproteins E6 and E7, which inactivate the p53 and RB1 proteins, respecti...

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Detalles Bibliográficos
Autores principales: Williams, Erik A., Montesion, Meagan, Lincoln, Vadim, Tse, Julie Y., Hiemenz, Matthew C., Mata, Douglas A., Shah, Bhamini B., Shoroye, Adebowale, Alexander, Brian M., Werth, Adrienne J., Foley-Peres, Kathleen, Milante, Riza R., Ross, Jeffrey S., Ramkissoon, Shakti H., Williams, Kevin Jon, Adhikari, Laura J., Zuna, Rosemary E., LeBoit, Philip E., Lin, Douglas I., Elvin, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093731/
https://www.ncbi.nlm.nih.gov/pubmed/35034043
http://dx.doi.org/10.1097/PAS.0000000000001862

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