Cargando…
Topoisomerase IB: a relaxing enzyme for stressed DNA
DNA topoisomerase I enzymes relieve the torsional strain in DNA; they are essential for fundamental molecular processes such as DNA replication, transcription, recombination, and chromosome condensation; and act by cleaving and then religating DNA strands. Over the past few decades, scientists have...
Autores principales: | Soren, Bini Chhetri, Dasari, Jagadish Babu, Ottaviani, Alessio, Iacovelli, Federico, Fiorani, Paola |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
OAE Publishing Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094055/ https://www.ncbi.nlm.nih.gov/pubmed/35582040 http://dx.doi.org/10.20517/cdr.2019.106 |
Ejemplares similares
-
In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB
por: Soren, Bini Chhetri, et al.
Publicado: (2021) -
Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB
por: Ottaviani, Alessio, et al.
Publicado: (2021) -
Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B
por: Ottaviani, Alessio, et al.
Publicado: (2022) -
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
por: Tesauro, Cinzia, et al.
Publicado: (2013) -
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance
por: Losasso, Carmen, et al.
Publicado: (2008)