Cargando…

Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy

Ovarian carcinoma is one of the most common causes for cancer death in women; lack of early diagnosis and acquired resistance to platinum-based chemotherapy account for its poor prognosis and high mortality rate. As with other cancer types, ovarian cancer is characterized by dysregulated signaling p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romagnoli, Alice, Maracci, Cristina, D’Agostino, Mattia, Teana, Anna La, Marino, Daniele Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OAE Publishing Inc. 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094073/ https://www.ncbi.nlm.nih.gov/pubmed/35582305 http://dx.doi.org/10.20517/cdr.2021.20

Ejemplares similares

Control of the eIF4E activity: structural insights and pharmacological implications
por: Romagnoli, Alice, et al.
Publicado: (2021)

The Role of mTOR and eIF Signaling in Benign Endometrial Diseases
por: Driva, Tatiana S., et al.
Publicado: (2022)

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio
por: Alain, Tommy, et al.
Publicado: (2012)

Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors
por: D'Agostino, Mattia, et al.
Publicado: (2020)

eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome
por: Weiss, Benjamin, et al.
Publicado: (2021)

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling
por: Shen, Peng, et al.
Publicado: (2018)

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
por: Satheesha, Sampoorna, et al.
Publicado: (2011)

Structural–Functional Relationship of the Ribonucleolytic Activity of aIF5A from Sulfolobus solfataricus
por: Romagnoli, Alice, et al.
Publicado: (2022)

Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes
por: Martella, Marianna, et al.
Publicado: (2020)

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
por: Ramírez-Valle, Francisco, et al.
Publicado: (2008)

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer
por: Matsumoto, Masaru, et al.
Publicado: (2015)

Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway
por: Susor, Andrej, et al.
Publicado: (2015)

A Critical Role of the mTOR/eIF2α Pathway in Hypoxia-Induced Pulmonary Hypertension
por: Wang, Ai-ping, et al.
Publicado: (2015)

eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway
por: Sun, Liping, et al.
Publicado: (2021)

Requirement for the eIF4E Binding Proteins for the Synergistic Down-Regulation of Protein Synthesis by Hypertonic Conditions and mTOR Inhibition
por: Clemens, Michael J., et al.
Publicado: (2013)

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1
por: Grosso, Stefano, et al.
Publicado: (2011)

Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives
por: Sesma, Ane, et al.
Publicado: (2017)

The Androgen Receptor is a negative regulator of eIF4E Phosphorylation at S209: Implications for the use of mTOR inhibitors in advanced prostate cancer
por: D’Abronzo, Leandro S., et al.
Publicado: (2017)

Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia
por: Shi, Fangfang, et al.
Publicado: (2015)

mTOR downstream effectors, 4EBP1 and eIF4E, are overexpressed and associated with HPV status in precancerous lesions and carcinomas of the uterine cervix
por: Asimomytis, Aristidis, et al.
Publicado: (2016)

In vitro Anti-Hantavirus Activity of Protein Kinase Inhibitor 8G1 Targeting AKT/mTOR/eIF4E Signaling Pathway
por: Li, Zhoupeng, et al.
Publicado: (2022)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1
por: Tsai, Becky Pinjou, et al.
Publicado: (2014)

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts
por: Chaparro, Visnu, et al.
Publicado: (2020)

eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage
por: Ma, Shijie, et al.
Publicado: (2022)

eIF4E Overexpression Is Associated with Poor Prognoses of Ovarian Cancer
por: Zheng, Jun, et al.
Publicado: (2020)

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells
por: Lineham, Ella, et al.
Publicado: (2018)

Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming
por: Geter, Phillip A., et al.
Publicado: (2017)

Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer
por: Lu, Junmi, et al.
Publicado: (2020)

Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study
por: Soliman, Ghada A., et al.
Publicado: (2020)

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
por: Zakaria, Chadi, et al.
Publicado: (2018)

The Translation Regulatory Subunit eIF3f Controls the Kinase-Dependent mTOR Signaling Required for Muscle Differentiation and Hypertrophy in Mouse
por: Csibi, Alfredo, et al.
Publicado: (2010)

Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma
por: Demosthenous, Christos, et al.
Publicado: (2015)

eIF4A1 Inhibitor Suppresses Hyperactive mTOR-Associated Tumors by Inducing Necroptosis and G2/M Arrest
por: Han, Luyang, et al.
Publicado: (2022)

An eIF for proliferation
por: LeBrasseur, Nicole
Publicado: (2008)

The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells
por: González-Almela, Esther, et al.
Publicado: (2018)

Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions
por: Yoffe, Yael, et al.
Publicado: (2009)

Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D
por: Sanz, Miguel Angel, et al.
Publicado: (2017)

eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle
por: Harms, Ulf, et al.
Publicado: (2014)

Selectivity for eIF4E
por: LeBrasseur, Nicole
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_o114rsqto5it8vap0dpris3oae