Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

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The Papain-like protease (PLpro) is a domain of a multi-functional, non-structural protein 3 of coronaviruses. PLpro cleaves viral polyproteins and posttranslational conjugates with polyubiquitin and protective ISG15, composed of two ubiquitin-like (UBL) domains. Across coronaviruses, PLpro showed d...

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Detalles Bibliográficos
Autores principales: Wydorski, Pawel M., Osipiuk, Jerzy, Lanham, Benjamin T., Tesar, Christine, Endres, Michael, Engle, Elizabeth, Jedrzejczak, Robert, Mullapudi, Vishruth, Michalska, Karolina, Fidelis, Krzysztof, Fushman, David, Joachimiak, Andrzej, Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094096/
https://www.ncbi.nlm.nih.gov/pubmed/35547846
http://dx.doi.org/10.1101/2021.09.15.460543
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