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Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model

Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH...

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Autores principales: Sato, Akira, Tagai, Nozomi, Ogino, Yoko, Uozumi, Haruka, Kawakami, Shinpei, Yamamoto, Takayuki, Tanuma, Sei‐ichi, Maruki‐Uchida, Hiroko, Mori, Sadao, Morita, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094456/
https://www.ncbi.nlm.nih.gov/pubmed/35592293
http://dx.doi.org/10.1002/fsn3.2757
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author Sato, Akira
Tagai, Nozomi
Ogino, Yoko
Uozumi, Haruka
Kawakami, Shinpei
Yamamoto, Takayuki
Tanuma, Sei‐ichi
Maruki‐Uchida, Hiroko
Mori, Sadao
Morita, Minoru
author_facet Sato, Akira
Tagai, Nozomi
Ogino, Yoko
Uozumi, Haruka
Kawakami, Shinpei
Yamamoto, Takayuki
Tanuma, Sei‐ichi
Maruki‐Uchida, Hiroko
Mori, Sadao
Morita, Minoru
author_sort Sato, Akira
collection PubMed
description Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH‐SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH‐SY5Y cells. Both PFSE and piceatannol were found to protect Aβ‐induced neurite fragmentation in the cell model (protection efficacy; 34% in PFSE and 36% in piceatannol). In addition, both PFSE and piceatannol suppress Aβ‐induced neuronal cell death in the cell model (inhibitory effect; 27% in PFSE and 32% in piceatannol). Our study is the first to report that piceatannol‐rich PFSE can repress Aβ‐induced neuronal cell death by protecting against neurite fragmentation in the AD human cell model. These findings suggest that piceatannol‐rich PFSE can be considered a potentially neuroprotective functional food for both prevention and treatment of AD.
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spelling pubmed-90944562022-05-18 Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model Sato, Akira Tagai, Nozomi Ogino, Yoko Uozumi, Haruka Kawakami, Shinpei Yamamoto, Takayuki Tanuma, Sei‐ichi Maruki‐Uchida, Hiroko Mori, Sadao Morita, Minoru Food Sci Nutr Original Articles Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH‐SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH‐SY5Y cells. Both PFSE and piceatannol were found to protect Aβ‐induced neurite fragmentation in the cell model (protection efficacy; 34% in PFSE and 36% in piceatannol). In addition, both PFSE and piceatannol suppress Aβ‐induced neuronal cell death in the cell model (inhibitory effect; 27% in PFSE and 32% in piceatannol). Our study is the first to report that piceatannol‐rich PFSE can repress Aβ‐induced neuronal cell death by protecting against neurite fragmentation in the AD human cell model. These findings suggest that piceatannol‐rich PFSE can be considered a potentially neuroprotective functional food for both prevention and treatment of AD. John Wiley and Sons Inc. 2022-02-02 /pmc/articles/PMC9094456/ /pubmed/35592293 http://dx.doi.org/10.1002/fsn3.2757 Text en © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Sato, Akira
Tagai, Nozomi
Ogino, Yoko
Uozumi, Haruka
Kawakami, Shinpei
Yamamoto, Takayuki
Tanuma, Sei‐ichi
Maruki‐Uchida, Hiroko
Mori, Sadao
Morita, Minoru
Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title_full Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title_fullStr Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title_full_unstemmed Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title_short Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
title_sort passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma sh‐sy5y cell model
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094456/
https://www.ncbi.nlm.nih.gov/pubmed/35592293
http://dx.doi.org/10.1002/fsn3.2757
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