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Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model
Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094456/ https://www.ncbi.nlm.nih.gov/pubmed/35592293 http://dx.doi.org/10.1002/fsn3.2757 |
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author | Sato, Akira Tagai, Nozomi Ogino, Yoko Uozumi, Haruka Kawakami, Shinpei Yamamoto, Takayuki Tanuma, Sei‐ichi Maruki‐Uchida, Hiroko Mori, Sadao Morita, Minoru |
author_facet | Sato, Akira Tagai, Nozomi Ogino, Yoko Uozumi, Haruka Kawakami, Shinpei Yamamoto, Takayuki Tanuma, Sei‐ichi Maruki‐Uchida, Hiroko Mori, Sadao Morita, Minoru |
author_sort | Sato, Akira |
collection | PubMed |
description | Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH‐SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH‐SY5Y cells. Both PFSE and piceatannol were found to protect Aβ‐induced neurite fragmentation in the cell model (protection efficacy; 34% in PFSE and 36% in piceatannol). In addition, both PFSE and piceatannol suppress Aβ‐induced neuronal cell death in the cell model (inhibitory effect; 27% in PFSE and 32% in piceatannol). Our study is the first to report that piceatannol‐rich PFSE can repress Aβ‐induced neuronal cell death by protecting against neurite fragmentation in the AD human cell model. These findings suggest that piceatannol‐rich PFSE can be considered a potentially neuroprotective functional food for both prevention and treatment of AD. |
format | Online Article Text |
id | pubmed-9094456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90944562022-05-18 Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model Sato, Akira Tagai, Nozomi Ogino, Yoko Uozumi, Haruka Kawakami, Shinpei Yamamoto, Takayuki Tanuma, Sei‐ichi Maruki‐Uchida, Hiroko Mori, Sadao Morita, Minoru Food Sci Nutr Original Articles Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain‐derived neurotrophic factor (BDNF) promoted beta‐amyloid (Aβ)‐induced neuronal cell death in neuron‐like differentiated SH‐SY5Y (ndSH‐SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH‐SY5Y cells. Both PFSE and piceatannol were found to protect Aβ‐induced neurite fragmentation in the cell model (protection efficacy; 34% in PFSE and 36% in piceatannol). In addition, both PFSE and piceatannol suppress Aβ‐induced neuronal cell death in the cell model (inhibitory effect; 27% in PFSE and 32% in piceatannol). Our study is the first to report that piceatannol‐rich PFSE can repress Aβ‐induced neuronal cell death by protecting against neurite fragmentation in the AD human cell model. These findings suggest that piceatannol‐rich PFSE can be considered a potentially neuroprotective functional food for both prevention and treatment of AD. John Wiley and Sons Inc. 2022-02-02 /pmc/articles/PMC9094456/ /pubmed/35592293 http://dx.doi.org/10.1002/fsn3.2757 Text en © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Sato, Akira Tagai, Nozomi Ogino, Yoko Uozumi, Haruka Kawakami, Shinpei Yamamoto, Takayuki Tanuma, Sei‐ichi Maruki‐Uchida, Hiroko Mori, Sadao Morita, Minoru Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title | Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title_full | Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title_fullStr | Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title_full_unstemmed | Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title_short | Passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma SH‐SY5Y cell model |
title_sort | passion fruit seed extract protects beta‐amyloid‐induced neuronal cell death in a differentiated human neuroblastoma sh‐sy5y cell model |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094456/ https://www.ncbi.nlm.nih.gov/pubmed/35592293 http://dx.doi.org/10.1002/fsn3.2757 |
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