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Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants

Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that...

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Autores principales: Monreal, Gretel, Koenig, Steven C., Slaughter, Mark S., Morello, Gino F., Prina, Steven R., Tompkins, Landon H., Huang, Jiapeng, Gellman, Barry N., Dasse, Kurt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094552/
https://www.ncbi.nlm.nih.gov/pubmed/35544516
http://dx.doi.org/10.1371/journal.pone.0266822
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author Monreal, Gretel
Koenig, Steven C.
Slaughter, Mark S.
Morello, Gino F.
Prina, Steven R.
Tompkins, Landon H.
Huang, Jiapeng
Gellman, Barry N.
Dasse, Kurt A.
author_facet Monreal, Gretel
Koenig, Steven C.
Slaughter, Mark S.
Morello, Gino F.
Prina, Steven R.
Tompkins, Landon H.
Huang, Jiapeng
Gellman, Barry N.
Dasse, Kurt A.
author_sort Monreal, Gretel
collection PubMed
description Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that will be housed in a single compact unit. Conceptually, the primary innovation of this technology will be the combination of disposable, low-cost pumps for use with a single, multi-functional, universal controller to support multiple pediatric cardiopulmonary indications. In response to the paucity of clinically available pediatric devices, Inspired Therapeutics is specifically targeting the underserved neonate and infant heart failure (HF) patient population first. In this article, we present the development of the prototype Inspired Therapeutics NeoMate System for pediatric left ventricular assist device (LVAD) support, and feasibility testing in static mock flow loops (H-Q curves), dynamic mock flow loops (hemodynamics), and in an acute healthy ovine model (hemodynamics and clinical applicability). The resultant hydrodynamic and hemodynamic data demonstrated the ability of this prototype pediatric LVAD and universal controller to function over a range of rotary pump speeds (500–6000 RPM), to provide pump flow rates of up to 2.6 L/min, and to volume unload the left ventricle in acute animals. Key engineering challenges observed and proposed solutions for the next design iteration are also presented.
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spelling pubmed-90945522022-05-12 Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants Monreal, Gretel Koenig, Steven C. Slaughter, Mark S. Morello, Gino F. Prina, Steven R. Tompkins, Landon H. Huang, Jiapeng Gellman, Barry N. Dasse, Kurt A. PLoS One Research Article Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that will be housed in a single compact unit. Conceptually, the primary innovation of this technology will be the combination of disposable, low-cost pumps for use with a single, multi-functional, universal controller to support multiple pediatric cardiopulmonary indications. In response to the paucity of clinically available pediatric devices, Inspired Therapeutics is specifically targeting the underserved neonate and infant heart failure (HF) patient population first. In this article, we present the development of the prototype Inspired Therapeutics NeoMate System for pediatric left ventricular assist device (LVAD) support, and feasibility testing in static mock flow loops (H-Q curves), dynamic mock flow loops (hemodynamics), and in an acute healthy ovine model (hemodynamics and clinical applicability). The resultant hydrodynamic and hemodynamic data demonstrated the ability of this prototype pediatric LVAD and universal controller to function over a range of rotary pump speeds (500–6000 RPM), to provide pump flow rates of up to 2.6 L/min, and to volume unload the left ventricle in acute animals. Key engineering challenges observed and proposed solutions for the next design iteration are also presented. Public Library of Science 2022-05-11 /pmc/articles/PMC9094552/ /pubmed/35544516 http://dx.doi.org/10.1371/journal.pone.0266822 Text en © 2022 Monreal et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Monreal, Gretel
Koenig, Steven C.
Slaughter, Mark S.
Morello, Gino F.
Prina, Steven R.
Tompkins, Landon H.
Huang, Jiapeng
Gellman, Barry N.
Dasse, Kurt A.
Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title_full Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title_fullStr Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title_full_unstemmed Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title_short Feasibility testing of the Inspired Therapeutics NeoMate mechanical circulatory support system for neonates and infants
title_sort feasibility testing of the inspired therapeutics neomate mechanical circulatory support system for neonates and infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094552/
https://www.ncbi.nlm.nih.gov/pubmed/35544516
http://dx.doi.org/10.1371/journal.pone.0266822
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