IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system

Several subunits in the matrix domain of mitochondrial complex I (CI) have been posited to be redox sensors for CI, but how elevated levels of reactive oxygen species (ROS) impinge on CI assembly is unknown. We report that genetic disruption of the mitochondrial NADPH-generating enzyme, isocitrate d...

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Detalles Bibliográficos
Autores principales: Murari, Anjaneyulu, Goparaju, Naga S. V., Rhooms, Shauna-Kay, Hossain, Kaniz F. B., Liang, Felix G., Garcia, Christian J., Osei, Cindy, Liu, Tong, Li, Hong, Kitsis, Richard N., Patel, Rajesh, Owusu-Ansah, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094667/
https://www.ncbi.nlm.nih.gov/pubmed/35544578
http://dx.doi.org/10.1126/sciadv.abl8716

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