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Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Epitopes that bind simultaneously to all human alleles of Major Histocompatibility Complex class II (MHC II) are considered one of the key factors for the development of improved vaccines and cancer immunotherapies. To engineer MHC II multiple-allele binders, we developed a protocol called PanMHC-PA...

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Detalles Bibliográficos
Autores principales:	Ochoa, Rodrigo, Lunardelli, Victoria Alves Santos, Rosa, Daniela Santoro, Laio, Alessandro, Cossio, Pilar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094701/ https://www.ncbi.nlm.nih.gov/pubmed/35572587 http://dx.doi.org/10.3389/fimmu.2022.862851

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