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Measuring the tolerance of the genetic code to altered codon size

Translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet codon, rather than quadruplet codon, genetic code? Here, we investigate the tolerance of the Escherichia coli genetic code to tRNA mutations that incre...

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Detalles Bibliográficos
Autores principales: DeBenedictis, Erika Alden, Söll, Dieter, Esvelt, Kevin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094753/
https://www.ncbi.nlm.nih.gov/pubmed/35293861
http://dx.doi.org/10.7554/eLife.76941

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