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Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis

Doxorubicin (DOX) is an efficient antitumor anthracycline drug, but its cardiotoxicity adversely affects the prognosis of the patients. In this study, we explored whether endogenous gasotransmitter hydrogen sulfide (H(2)S) could protect against DOX-induced cardiomyocyte apoptosis and its mechanisms....

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Detalles Bibliográficos
Autores principales:	Ye, Xiaoyun, Li, Yingying, Lv, Boyang, Qiu, Bingquan, Zhang, Shangyue, Peng, Hanlin, Kong, Wei, Tang, Chaoshu, Huang, Yaqian, Du, Junbao, Jin, Hongfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095366/ https://www.ncbi.nlm.nih.gov/pubmed/35571249 http://dx.doi.org/10.1155/2022/6153772

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