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Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes

BACKGROUND: Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the e...

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Autores principales: Biswas, Koushik, McLay, James, Campbell, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095401/
https://www.ncbi.nlm.nih.gov/pubmed/35571749
http://dx.doi.org/10.1155/2022/4715965
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author Biswas, Koushik
McLay, James
Campbell, Fiona M.
author_facet Biswas, Koushik
McLay, James
Campbell, Fiona M.
author_sort Biswas, Koushik
collection PubMed
description BACKGROUND: Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes. MATERIALS AND METHODS: Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Only randomised controlled trials on human subjects reported in English and published up to October 2021 were included. Quality assessments were conducted using the modified Downs and Black quality assessment tool. Data were extracted using a narrative synthesis. RESULTS: Twenty-two articles were included in our systematic review (seventeen reported on maternal outcomes, two on newborn outcomes, and three on both). Maternal studies reported the effects of selenium supplementation in the prevention of thyroid dysfunction, gestational diabetes, pregnancy-induced hypertension/preeclampsia, oxidative stress, postpartum depression, premature rupture of membranes, intrauterine growth retardation, breastmilk composition, and HIV-positive women. Newborn studies reported the effects of maternal selenium supplementation on foetal oxidation stress, foetal lipid profile, neonatal hyperbilirubinemia, and newborn outcomes in HIV-positive mothers. The majority of studies were inappropriately designed to establish clinical or scientific utility. Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres. CONCLUSION: The evidence supporting selenium supplementation during pregnancy is poor and there is a need for appropriately designed randomised controlled trials before routine use can be recommended.
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spelling pubmed-90954012022-05-12 Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes Biswas, Koushik McLay, James Campbell, Fiona M. J Nutr Metab Research Article BACKGROUND: Several studies have suggested that increased oxidative stress during pregnancy may be associated with adverse maternal and foetal outcomes. As selenium is an essential mineral with an antioxidant role, our aim was to perform a systematic review of the existing literature reporting the effects of selenium supplementation during pregnancy on maternal and neonatal outcomes. MATERIALS AND METHODS: Six electronic databases (Medline, Embase, Cochrane Library, Web of Science, Scopus, and PubMed) were searched for studies reporting the effects of selenium supplementation during pregnancy and the postpartum period on maternal and neonatal outcomes. Only randomised controlled trials on human subjects reported in English and published up to October 2021 were included. Quality assessments were conducted using the modified Downs and Black quality assessment tool. Data were extracted using a narrative synthesis. RESULTS: Twenty-two articles were included in our systematic review (seventeen reported on maternal outcomes, two on newborn outcomes, and three on both). Maternal studies reported the effects of selenium supplementation in the prevention of thyroid dysfunction, gestational diabetes, pregnancy-induced hypertension/preeclampsia, oxidative stress, postpartum depression, premature rupture of membranes, intrauterine growth retardation, breastmilk composition, and HIV-positive women. Newborn studies reported the effects of maternal selenium supplementation on foetal oxidation stress, foetal lipid profile, neonatal hyperbilirubinemia, and newborn outcomes in HIV-positive mothers. The majority of studies were inappropriately designed to establish clinical or scientific utility. Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres. CONCLUSION: The evidence supporting selenium supplementation during pregnancy is poor and there is a need for appropriately designed randomised controlled trials before routine use can be recommended. Hindawi 2022-05-04 /pmc/articles/PMC9095401/ /pubmed/35571749 http://dx.doi.org/10.1155/2022/4715965 Text en Copyright © 2022 Koushik Biswas et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Biswas, Koushik
McLay, James
Campbell, Fiona M.
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title_full Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title_fullStr Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title_full_unstemmed Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title_short Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
title_sort selenium supplementation in pregnancy-maternal and newborn outcomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095401/
https://www.ncbi.nlm.nih.gov/pubmed/35571749
http://dx.doi.org/10.1155/2022/4715965
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