Age-dependent formation of TMEM106B amyloid filaments in human brains

Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and transactive response DNA-binding protein (TARDBP; also known as TDP-43) are the mo...

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Detalles Bibliográficos
Autores principales: Schweighauser, Manuel, Arseni, Diana, Bacioglu, Mehtap, Huang, Melissa, Lövestam, Sofia, Shi, Yang, Yang, Yang, Zhang, Wenjuan, Kotecha, Abhay, Garringer, Holly J., Vidal, Ruben, Hallinan, Grace I., Newell, Kathy L., Tarutani, Airi, Murayama, Shigeo, Miyazaki, Masayuki, Saito, Yuko, Yoshida, Mari, Hasegawa, Kazuko, Lashley, Tammaryn, Revesz, Tamas, Kovacs, Gabor G., van Swieten, John, Takao, Masaki, Hasegawa, Masato, Ghetti, Bernardino, Spillantini, Maria Grazia, Ryskeldi-Falcon, Benjamin, Murzin, Alexey G., Goedert, Michel, Scheres, Sjors H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095482/
https://www.ncbi.nlm.nih.gov/pubmed/35344985
http://dx.doi.org/10.1038/s41586-022-04650-z

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