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Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K(ATP) channel pathway

Alzheimer’s disease (AD) is characterized by the deposition of amyloid β peptide (Aβ) in the brain. The neuropeptide somatostatin (SST) regulates Aβ catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism by which SST regulates NEP activity remains unclear....

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Detalles Bibliográficos
Autores principales:	Watamura, Naoto, Kakiya, Naomasa, Nilsson, Per, Tsubuki, Satoshi, Kamano, Naoko, Takahashi, Mika, Hashimoto, Shoko, Sasaguri, Hiroki, Saito, Takashi, Saido, Takaomi C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095489/ https://www.ncbi.nlm.nih.gov/pubmed/34737456 http://dx.doi.org/10.1038/s41380-021-01368-8

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